Joshua K Hakimian
Overview
Explore the profile of Joshua K Hakimian including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
124
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Recent Articles
1.
Severino A, Mittal N, Hakimian J, Velarde N, Minasyan A, Albert R, et al.
eNeuro
. 2020 Aug;
7(5).
PMID: 32859725
μ-Opioid receptors (MORs) are densely expressed in different brain regions known to mediate reward. One such region is the striatum where MORs are densely expressed, yet the role of these...
2.
Hakimian J, Dong T, Barahona J, Lagishetty V, Tiwari S, Azani D, et al.
Nutrients
. 2019 Aug;
11(8).
PMID: 31416242
Opioids are highly addictive substances with a relapse rate of over 90%. While preclinical models of chronic opioid exposure exist for studying opioid dependence, none recapitulate the relapses observed in...
3.
Liu S, Pickens S, Burma N, Ibarra-Lecue I, Yang H, Xue L, et al.
J Neurosci
. 2019 Mar;
39(21):4162-4178.
PMID: 30862664
Pain is a multidimensional experience and negative affect, or how much the pain is "bothersome", significantly impacts the sufferers' quality of life. It is well established that the κ opioid...
4.
Severino A, Shadfar A, Hakimian J, Crane O, Singh G, Heinzerling K, et al.
Front Psychiatry
. 2018 May;
9:119.
PMID: 29740351
Prescription opioid misuse is an ongoing and escalating epidemic. Although these pharmacological agents are highly effective analgesics prescribed for different types of pain, opioids also induce euphoria, leading to increasing...
5.
Severino A, Chen W, Hakimian J, Kieffer B, Gaveriaux-Ruff C, Walwyn W, et al.
Pain
. 2018 Apr;
159(8):1607-1620.
PMID: 29677019
The latent sensitization model of chronic pain reveals that recovery from some types of long-term hyperalgesia is an altered state in which nociceptive sensitization persists but is suppressed by the...
6.
Mittal N, Minasyan A, Romaneschi N, Hakimian J, Gonzalez-Fernandez G, Albert R, et al.
PLoS One
. 2017 Oct;
12(10):e0185796.
PMID: 28973019
The two highly homologous non-visual arrestins, beta-arrestin 1 and 2, are ubiquitously expressed in the central nervous system, yet knowledge of their disparate roles is limited. While beta-arrestin 2 (βarr2)...