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Joshua D Strauss

Explore the profile of Joshua D Strauss including associated specialties, affiliations and a list of published articles. Areas
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Articles 16
Citations 411
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Recent Articles
1.
Strauss J, Gilbert M, Mehta M, Li A, Zhou R, Ms R, et al.
Neuro Oncol . 2024 Nov; 27(3):767-778. PMID: 39549280
Background: Glioblastoma (GBM) is an aggressive form of brain cancer in which treatment is associated with toxicities that can result in therapy discontinuation or death. This analysis investigated clinical and...
2.
Strauss J, Brown D, Zhou W, Dagnall C, Yuan J, Im A, et al.
Br J Haematol . 2024 Aug; 205(3):1180-1187. PMID: 39103182
Severe aplastic anaemia (SAA) is a rare and life-threatening bone marrow failure disorder. We used data from the transplant outcomes in aplastic anaemia study to characterize mosaic chromosomal alterations (mCAs)...
3.
Aleksandrov L, Aleksandrov A, Jensen T, Strauss J, Fay J
Int J Mol Sci . 2022 Aug; 23(16). PMID: 36012518
Cystic fibrosis transmembrane regulator (CFTR) is a dynamic membrane protein belonging to the ABC transporter family. It is unusual within this family as it is an ion channel, as opposed...
4.
Budziszewski G, Zhao Y, Spangler C, Kedziora K, Williams M, Azzam D, et al.
Nucleic Acids Res . 2022 Apr; 50(8):4355-4371. PMID: 35390161
A key role of chromatin kinases is to phosphorylate histone tails during mitosis to spatiotemporally regulate cell division. Vaccinia-related kinase 1 (VRK1) is a serine-threonine kinase that phosphorylates histone H3...
5.
Peck J, Fay J, Strauss J
IUCrJ . 2022 Apr; 9(Pt 2):243-252. PMID: 35371504
Limitations to successful single-particle cryo-electron microscopy (cryo-EM) projects include stable sample generation, production of quality cryo-EM grids with randomly oriented particles embedded in thin vitreous ice and access to microscope...
6.
Lim C, Ramsey J, Hwang D, Teixeira S, Poon C, Strauss J, et al.
Small . 2021 Nov; 18(4):e2103552. PMID: 34841670
Significant advances in physicochemical properties of polymeric micelles enable optimization of therapeutic drug efficacy, supporting nanomedicine manufacturing and clinical translation. Yet, the effect of micelle morphology on pharmacological efficacy is...
7.
Boyer J, Spangler C, Strauss J, Cesmat A, Liu P, McGinty R, et al.
Science . 2020 Sep; 370(6515):450-454. PMID: 32913000
Cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) synthase (cGAS) recognizes cytosolic foreign or damaged DNA to activate the innate immune response to infection, inflammatory diseases, and cancer. By contrast, cGAS reactivity...
8.
Gunn K, Roberts B, Wang F, Strauss J, Borgnia M, Egelman E, et al.
Proc Natl Acad Sci U S A . 2020 Apr; 117(19):10254-10264. PMID: 32332168
Lipases are enzymes necessary for the proper distribution and utilization of lipids in the human body. Lipoprotein lipase (LPL) is active in capillaries, where it plays a crucial role in...
9.
Dillard R, Hampton C, Strauss J, Ke Z, Altomara D, Guerrero-Ferreira R, et al.
Microsc Microanal . 2018 Sep; 24(4):406-419. PMID: 30175702
Cryo-electron microscopy (cryo-EM) is a powerful tool for macromolecular to near-atomic resolution structure determination in the biological sciences. The specimen is maintained in a near-native environment within a thin film...
10.
Ke Z, Dillard R, Chirkova T, Leon F, Stobart C, Hampton C, et al.
Viruses . 2018 Aug; 10(8). PMID: 30127286
Human respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract disease in young children. With repeat infections throughout life, it can also cause substantial disease in the...