Joshua D Breidenbach
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Explore the profile of Joshua D Breidenbach including associated specialties, affiliations and a list of published articles.
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24
Citations
169
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Recent Articles
1.
French B, Breidenbach J, Yassine S, Khatib-Shahidi B, Kazmi S, Murphy C, et al.
Cells
. 2025 Jan;
13(24.
PMID: 39768208
Commonly used adenine-induced chronic kidney disease (CKD) murine models often employ C57BL/6 mice; however, this strain has inherent limitations due to its natural resistance to developing key pathological features of...
2.
Breidenbach J, French B, Stanoszek L, Lavik J, Maddipati K, Premathilaka S, et al.
Toxins (Basel)
. 2024 Nov;
16(11).
PMID: 39591225
Harmful algal blooms are increasing globally and pose serious health concerns releasing cyanotoxins. Microcystin-LR (MC-LR), one of the most frequently produced cyanotoxins, has recently been detected in aerosols generated by...
3.
Breidenbach J, Rivera E, Harvey T, Mikolitis A, Tseng C, Sanders C, et al.
Anal Chem
. 2024 Oct;
96(46):18343-18348.
PMID: 39382659
Omics-based measurements enable the study of biomolecules in a high-throughput fashion, leading to the characterization and quantification of biological systems. Multi-omics methods aim to incorporate several omics measurements for a...
4.
Rivera E, LeBrun E, Breidenbach J, Solomon E, Sanders C, Harvey T, et al.
Toxicol Sci
. 2024 Aug;
202(1):85-95.
PMID: 39110521
Although classical molecular biology assays can provide a measure of cellular response to chemical challenges, they rely on a single biological phenomenon to infer a broader measure of cellular metabolic...
5.
Aradhyula V, Breidenbach J, Khatib-Shahidi B, Slogar J, Eyong S, Faleel D, et al.
Genes (Basel)
. 2024 Jul;
15(7).
PMID: 39062733
Arachidonic acid (AA) metabolites have been associated with several diseases across various organ systems, including the cardiovascular, pulmonary, and renal systems. Lipid mediators generated from AA oxidation have been studied...
6.
Hogberg H, Tsaioun K, Breidenbach J, Elmore B, Filipovska J, Garcia-Reyero N, et al.
Neurotoxicology
. 2024 May;
103:16-26.
PMID: 38763473
Background: The global coronavirus 2019 (COVID-19) pandemic began in early 2020, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In mid-2020 the CIAO (Modelling the Pathogenesis of COVID-19 Using...
7.
Dube P, Aradhyula V, Lad A, Khalaf F, Breidenbach J, Kashaboina E, et al.
Int J Mol Sci
. 2023 Jun;
24(12).
PMID: 37373209
Diet-induced models of chronic kidney disease (CKD) offer several advantages, including clinical relevance and animal welfare, compared with surgical models. Oxalate is a plant-based, terminal toxic metabolite that is eliminated...
8.
Dube P, Khalaf F, DeRiso A, Mohammed C, Connolly J, Battepati D, et al.
Biomedicines
. 2022 Sep;
10(9).
PMID: 36140402
Paraoxonase-1 (PON-1) is a hydrolytic enzyme associated with HDL, contributing to its anti-inflammatory, antioxidant, and anti-atherogenic properties. Deficiencies in PON-1 activity result in oxidative stress and detrimental clinical outcomes in...
9.
Breidenbach J, French B, Gordon T, Kleinhenz A, Khalaf F, Willey J, et al.
Environ Int
. 2022 Sep;
169:107531.
PMID: 36137425
Harmful algal blooms plague bodies of freshwater globally. These blooms are often composed of outgrowths of cyanobacteria capable of producing the heptapeptide Microcystin-LR (MC-LR) which is a well-known hepatotoxin. Recently,...
10.
Lad A, Hunyadi J, Connolly J, Breidenbach J, Khalaf F, Dube P, et al.
Antioxidants (Basel)
. 2022 Aug;
11(8).
PMID: 36009344
We have previously shown in a murine model of Non-alcoholic Fatty Liver Disease (NAFLD) that chronic, low-dose exposure to the Harmful Algal Bloom cyanotoxin microcystin-LR (MC-LR), resulted in significant hepatotoxicity...