Joseph S Sparling
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Explore the profile of Joseph S Sparling including associated specialties, affiliations and a list of published articles.
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10
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677
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Recent Articles
1.
Assinck P, Sparling J, Dworski S, Duncan G, Wu D, Liu J, et al.
Stem Cell Reports
. 2020 Jun;
15(1):140-155.
PMID: 32559459
Cell transplantation for spinal cord injury (SCI) has largely been studied in sub-acute settings within 1-2 weeks of injury. In contrast, here we transplanted skin-derived precursors differentiated into Schwann cells...
2.
Chu T, Cummins K, Sparling J, Tsutsui S, Brideau C, Nilsson K, et al.
PLoS One
. 2017 Nov;
12(11):e0188218.
PMID: 29176903
As an extension of the brain, the spinal cord has unique properties which could allow us to gain a better understanding of CNS pathology. The brain and cord share the...
3.
Sparling J, Bretzner F, Biernaskie J, Assinck P, Jiang Y, Arisato H, et al.
J Neurosci
. 2015 May;
35(17):6714-30.
PMID: 25926450
The transplantation of Schwann cells (SCs) holds considerable promise as a therapy for spinal cord injury, but the optimal source of these cells and the best timing for intervention remains...
4.
Plemel J, Keough M, Duncan G, Sparling J, Yong V, Stys P, et al.
Prog Neurobiol
. 2014 Mar;
117:54-72.
PMID: 24582777
After spinal cord injury (SCI) there is prolonged and dispersed oligodendrocyte cell death that is responsible for widespread demyelination. To regenerate this lost myelin, many investigators have transplanted myelin-producing cells...
5.
Plemel J, Manesh S, Sparling J, Tetzlaff W
Glia
. 2013 Jul;
61(9):1471-87.
PMID: 23839973
Myelin loss is a hallmark of multiple sclerosis (MS) and promoting central nervous system myelin repair has become a major therapeutic target. Despite the presence of oligodendrocytes precursors cells (OPCs)...
6.
Plemel J, Chojnacki A, Sparling J, Liu J, Plunet W, Duncan G, et al.
Glia
. 2012 Mar;
59(12):1891-910.
PMID: 22407783
Spinal cord injury (SCI) results in substantial oligodendrocyte death and subsequent demyelination leading to white-matter defects. Cell replacement strategies to promote remyelination are under intense investigation; however, the optimal cell...
7.
Tetzlaff W, Okon E, Karimi-Abdolrezaee S, Hill C, Sparling J, Plemel J, et al.
J Neurotrauma
. 2010 Feb;
28(8):1611-82.
PMID: 20146557
Cell transplantation therapies have become a major focus in pre-clinical research as a promising strategy for the treatment of spinal cord injury (SCI). In this article, we systematically review the...
8.
Plemel J, Duncan G, Chen K, Shannon C, Park S, Sparling J, et al.
J Neurotrauma
. 2008 Apr;
25(4):350-70.
PMID: 18373484
Given the rising availability and use of genetically modified animals in basic science research, it has become increasingly important to develop clinically relevant models for spinal cord injury (SCI) for...
9.
Biernaskie J, Sparling J, Liu J, Shannon C, Plemel J, Xie Y, et al.
J Neurosci
. 2007 Sep;
27(36):9545-59.
PMID: 17804616
Transplantation of exogenous cells is one approach to spinal cord repair that could potentially enhance the growth and myelination of endogenous axons. Here, we asked whether skin-derived precursors (SKPs), a...
10.
Dringenberg H, Sparling J, Frazer J, Murdoch J
Exp Brain Res
. 2006 Apr;
174(1):114-23.
PMID: 16575576
The inferior colliculus (IC) is a critical component of the ascending projection system carrying auditory information from the brainstem to the forebrain. Recent evidence indicates that, in addition to its...