Joseph S Briguglio
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Explore the profile of Joseph S Briguglio including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
286
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Recent Articles
1.
Abbineni P, Briguglio J, Chapman E, Holz R, Axelrod D
Mol Biol Cell
. 2021 Dec;
33(6):ar53.
PMID: 34851717
Granule-plasma membrane docking and fusion can only occur when proteins that enable these reactions are present at the granule-plasma membrane contact. Thus, the mobility of granule membrane proteins may influence...
2.
Courtney N, Bao H, Briguglio J, Chapman E
Nat Commun
. 2019 Sep;
10(1):4076.
PMID: 31501440
Synaptic vesicle (SV) exocytosis is mediated by SNARE proteins. Reconstituted SNAREs are constitutively active, so a major focus has been to identify fusion clamps that regulate their activity in synapses:...
3.
Ruhl D, Bomba-Warczak E, Watson E, Bradberry M, Peterson T, Basu T, et al.
Nat Commun
. 2019 Aug;
10(1):3532.
PMID: 31387992
The synaptotagmin (syt) proteins have been widely studied for their role in regulating fusion of intracellular vesicles with the plasma membrane. Here we report that syt-17, an unusual isoform of...
4.
Xue R, Ruhl D, Briguglio J, Figueroa A, Pearce R, Chapman E
Proc Natl Acad Sci U S A
. 2018 May;
115(24):E5605-E5613.
PMID: 29844163
Various forms of synaptic plasticity underlie aspects of learning and memory. Synaptic augmentation is a form of short-term plasticity characterized by synaptic enhancement that persists for seconds following specific patterns...
5.
Courtney N, Briguglio J, Bradberry M, Greer C, Chapman E
Neuron
. 2018 May;
98(5):977-991.e5.
PMID: 29754754
Spontaneous neurotransmitter release (mini) is an important form of Ca-dependent synaptic transmission that occurs in the absence of action potentials. A molecular understanding of this process requires an identification of...
6.
Bao H, Das D, Courtney N, Jiang Y, Briguglio J, Lou X, et al.
Nature
. 2018 Feb;
554(7691):260-263.
PMID: 29420480
The fusion pore is the first crucial intermediate formed during exocytosis, yet little is known about the mechanisms that determine the size and kinetic properties of these transient structures. Here,...
7.
Roper L, Briguglio J, Evans C, Jackson M, Chapman E
Nat Commun
. 2015 Oct;
6:8645.
PMID: 26482442
The anterior pituitary releases six different hormones that control virtually all aspects of vertebrate physiology, yet the molecular mechanisms underlying their Ca(2+)-triggered release remain unknown. A subset of the synaptotagmin...
8.
Kumar S, Briguglio J, Turkewitz A
Eukaryot Cell
. 2015 Jun;
14(8):817-33.
PMID: 26092918
In many organisms, sophisticated mechanisms facilitate release of peptides in response to extracellular stimuli. In the ciliate Tetrahymena thermophila, efficient peptide secretion depends on specialized vesicles called mucocysts that contain...
9.
Kumar S, Briguglio J, Turkewitz A
Mol Biol Cell
. 2014 Jun;
25(16):2444-60.
PMID: 24943840
In Tetrahymena thermophila, peptides secreted via dense-core granules, called mucocysts, are generated by proprotein processing. We used expression profiling to identify candidate processing enzymes, which localized as cyan fluorescent protein...
10.
Briguglio J, Turkewitz A
J Exp Zool B Mol Dev Evol
. 2014 Mar;
322(7):500-16.
PMID: 24634411
Tetrahymena thermophila, a member of the Ciliates, represents a class of organisms distantly related from commonly used model organisms in cell biology, and thus offers an opportunity to explore potentially...