Joseph Orofino
Overview
Explore the profile of Joseph Orofino including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
74
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0
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Recent Articles
1.
Gao Y, Kwan J, Orofino J, Burrone G, Mitra S, Fan T, et al.
Pharmacol Res
. 2024 Aug;
207:107336.
PMID: 39094987
G-Protein Pathway Suppressor 2 (GPS2) is an inhibitor of non-proteolytic K63 ubiquitination mediated by the E2 ubiquitin-conjugating enzyme Ubc13. Previous studies have associated GPS2-mediated restriction of ubiquitination with the regulation...
2.
English J, Orofino J, Cederquist C, Paul I, Li H, Auwerx J, et al.
Mol Metab
. 2023 Feb;
69:101682.
PMID: 36731652
Objective: Dysfunctional, unhealthy expansion of white adipose tissue due to excess dietary intake is a process at the root of obesity and Type 2 Diabetes development. The objective of this...
3.
Cardamone M, Gao Y, Kwan J, Hayashi V, Sheeran M, Xu J, et al.
J Cell Biol
. 2022 Feb;
221(3).
PMID: 35157000
ADP-ribosylation is a reversible post-translational modification where an ADP-ribose moiety is covalently attached to target proteins by ADP-ribosyltransferases (ARTs). Although best known for its nuclear roles, ADP-ribosylation is increasingly recognized...
4.
Jones J, Rabhi N, Orofino J, Gamini R, Perissi V, Vernochet C, et al.
Sci Rep
. 2020 Feb;
10(1):2380.
PMID: 32047213
Visceral white adipose tissue (vWAT) expands and undergoes extensive remodeling during diet-induced obesity. Much is known about the contribution of various stromal vascular cells to the remodeling process, but less...
5.
Cardamone M, Orofino J, Labadorf A, Perissi V
J Vis Exp
. 2018 Dec;
(141).
PMID: 30531713
Most cellular processes are regulated by transcriptional modulation of specific gene programs. Such modulation is achieved through the combined actions of a wide range of transcription factors (TFs) and cofactors...
6.
Cederquist C, Lentucci C, Martinez-Calejman C, Hayashi V, Orofino J, Guertin D, et al.
Mol Metab
. 2017 Jan;
6(1):125-137.
PMID: 28123943
Objective: Insulin signaling plays a unique role in the regulation of energy homeostasis and the impairment of insulin action is associated with altered lipid metabolism, obesity, and Type 2 Diabetes....