Joseph Lunec
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Explore the profile of Joseph Lunec including associated specialties, affiliations and a list of published articles.
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24
Citations
1442
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Recent Articles
1.
Zhou L, Forman H, Ge Y, Lunec J
Toxicol In Vitro
. 2017 May;
42:292-298.
PMID: 28483489
Chemical functionalization broadens carbon nanotube (CNT) applications, conferring new functions, but at the same time potentially altering toxicity. Although considerable experimental data related to CNT toxicity, at the molecular and...
2.
Stebbeds W, Lunec J, Larcombe L
PLoS One
. 2012 Aug;
7(8):e43735.
PMID: 22928025
G-quadruplex structures, formed from guanine rich sequences, have previously been shown to be involved in various physiological processes including cancer-related gene expression. Furthermore, G-quadruplexes have been found in several oncogene...
3.
Bevan R, Mistry N, Patel P, Halligan E, Dove R, Lunec J
Br J Nutr
. 2009 Dec;
103(5):686-95.
PMID: 20003569
Intracellular vitamin C acts to protect cells against oxidative stress by intercepting reactive oxygen species (ROS) and minimising DNA damage. However, rapid increases in intracellular vitamin C may induce ROS...
4.
Mistry N, Bevan R, Cooke M, Evans M, Halligan E, Lowes D, et al.
Free Radic Res
. 2008 Apr;
42(4):344-53.
PMID: 18404533
Polyunsaturated fats have been linked to occurrences of sporadic colon cancer. One possible cause may be degradation of polyunsaturated fats during cooking, resulting in multiple reactive carbonyl species (RCS) that...
5.
Nell S, Bahtz R, Bossecker A, Kipp A, Landes N, Bumke-Vogt C, et al.
Free Radic Res
. 2007 Jul;
41(8):930-42.
PMID: 17654050
Global gene expression profiles of livers from mice, fed diets differing in alpha-tocopherol content, were compared using DNA microarray technology. Three hundred and eighty nine genes were found to significantly...
6.
Patel P, Bevan R, Mistry N, Lunec J
Free Radic Biol Med
. 2007 Feb;
42(4):552-8.
PMID: 17275687
The product of oxidative damage to DNA, 8-hydroxy-2'-deoxyguanosine (8-OHdG), when detected in urine, is considered to be a global, noninvasive biomarker of in vivo oxidative DNA damage. In this paper...
7.
Halligan E, Lowes D, Mistry N, Dove R, Cooke M, Evans M, et al.
Redox Rep
. 2007 Feb;
12(1):86-90.
PMID: 17263917
Oxidation of PUFAs in the diet has the potential to be genotoxic and hence carcinogenic. Such carcinogenic processes originate within stem cells of the colon. These cells appear to be...
8.
Grant M, Mistry N, Lunec J, Griffiths H
Br J Nutr
. 2007 Jan;
97(1):19-26.
PMID: 17217556
To investigate the hypothesis that the micronutrient ascorbic acid can modulate the functional genome, T cells (CCRF-HSB2) were treated with ascorbic acid (up to 150 microM) for up to 24...
9.
Woollard K, Rayment S, Bevan R, Shaw J, Lunec J, Griffiths H
Redox Rep
. 2006 Nov;
11(5):214-22.
PMID: 17132270
Vascular monocyte retention in the subintima is pivotal to the development of cardiovascular disease and is facilitated by up-regulation of adhesion molecules on monocytes/endothelial cells during oxidative stress. Epidemiological studies...
10.
Duarte T, Lunec J
Free Radic Res
. 2005 Jul;
39(7):671-86.
PMID: 16036346
Vitamin C (or ascorbic acid) is regarded as the most important water-soluble antioxidant in human plasma and mammalian cells which have mechanisms to recycle and accumulate it against a concentration...