Joseph J Goellner
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Explore the profile of Joseph J Goellner including associated specialties, affiliations and a list of published articles.
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10
Citations
636
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Recent Articles
1.
Fu Q, Bustamante-Gomez N, Reyes-Pardo H, Gubrij I, Escalona-Vargas D, Thostenson J, et al.
JCI Insight
. 2023 Aug;
8(18).
PMID: 37581932
Denosumab is an anti-RANKL Ab that potently suppresses bone resorption, increases bone mass, and reduces fracture risk. Discontinuation of denosumab causes rapid rebound bone resorption and bone loss, but the...
2.
Cawley K, Bustamante-Gomez N, Guha A, MacLeod R, Xiong J, Gubrij I, et al.
Cell Rep
. 2020 Sep;
32(10):108052.
PMID: 32905775
Osteoprotegerin (OPG) inhibits the ability of receptor activator of nuclear factor κB (NF-κB) ligand (RANKL) to stimulate the differentiation, activity, and survival of bone-resorbing osteoclasts. Genetic studies in mice show...
3.
Xiong J, Cawley K, Piemontese M, Fujiwara Y, Zhao H, Goellner J, et al.
Nat Commun
. 2018 Jul;
9(1):2909.
PMID: 30046091
Receptor activator of NFkB ligand (RANKL) is a TNF-family cytokine required for osteoclast formation, as well as immune cell and mammary gland development. It is produced as a membrane-bound protein...
4.
Fil D, DeLoach A, Yadav S, Alkam D, MacNicol M, Singh A, et al.
Hum Mol Genet
. 2017 Jan;
26(4):686-701.
PMID: 28040732
The recent identification of profilin1 mutations in 25 familial ALS cases has linked altered function of this cytoskeleton-regulating protein to the pathogenesis of motor neuron disease. To investigate the pathological...
5.
Xiong J, Piemontese M, Onal M, Campbell J, Goellner J, Dusevich V, et al.
PLoS One
. 2015 Sep;
10(9):e0138189.
PMID: 26393791
The cytokine receptor activator of nuclear factor kappa B ligand (RANKL), encoded by the Tnfsf11 gene, is essential for osteoclastogenesis and previous studies have shown that deletion of the Tnfsf11...
6.
Onal M, Bishop K, St John H, Danielson A, Riley E, Piemontese M, et al.
J Bone Miner Res
. 2014 Nov;
30(5):855-68.
PMID: 25431114
Receptor activator of NF-κB ligand (RANKL) is a TNFα-like cytokine that is produced by a diverse set of lineage-specific cells and is involved in a wide variety of physiological processes...
7.
Lee S, Goellner J, OBrien C, Pike J
Endocrinology
. 2014 Aug;
155(11):4137-48.
PMID: 25147982
The syndrome of hereditary 1,25-dihydroxyvitamin D-resistant rickets (HVDRR) is a genetic disease of altered mineral homeostasis due to mutations in the vitamin D receptor (VDR) gene. It is frequently, but...
8.
Lee S, Bishop K, Goellner J, OBrien C, Pike J
Endocrinology
. 2014 Apr;
155(6):2064-76.
PMID: 24693968
The biological actions of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) are mediated by the vitamin D receptor (VDR), which is expressed in numerous target tissues in a cell type-selective manner. Recent studies using...
9.
OBrien C, Plotkin L, Galli C, Goellner J, Gortazar A, Allen M, et al.
PLoS One
. 2008 Aug;
3(8):e2942.
PMID: 18698360
Osteocytes, former osteoblasts buried within bone, are thought to orchestrate skeletal adaptation to mechanical stimuli. However, it remains unknown whether hormones control skeletal homeostasis through actions on osteocytes. Parathyroid hormone...
10.
Qin W, Rudolph A, Bond B, Rocha R, Blomme E, Goellner J, et al.
Circ Res
. 2003 Jun;
93(1):69-76.
PMID: 12791709
Aldosterone classically promotes unidirectional transepithelial sodium transport, thereby regulating blood volume and blood pressure. Recently, both clinical and experimental studies have suggested additional, direct roles for aldosterone in the cardiovascular...