Joseph H Holthoff
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Explore the profile of Joseph H Holthoff including associated specialties, affiliations and a list of published articles.
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10
Citations
371
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Recent Articles
1.
Rai V, Singh M, Holthoff J
Genes (Basel)
. 2024 Oct;
15(10).
PMID: 39457385
Introduction: Autosomal dominant polycystic kidney disease (ADPKD) is one of the most prevalent heritable disorders, characterized by the progressive development of kidney cysts leading to renal failure. It is primarily...
2.
Holthoff J, Harville Y, Herzog C, Juncos L, Karakala N, Arthur J
BMC Nephrol
. 2023 Oct;
24(1):299.
PMID: 37821813
Background: Acute kidney injury (AKI) is a major burden among hospitalized and critical care patients. Among hospitalized patients that progress to severe AKI there is increased risk for morbidity, mortality,...
3.
Holthoff J, Chandrashekar K, Juncos L
Kidney360
. 2023 Jan;
3(12):1998-2000.
PMID: 36591366
No abstract available.
4.
Holthoff J, Wang Z, Patil N, Gokden N, Mayeux P
J Pharmacol Exp Ther
. 2013 Sep;
347(2):357-64.
PMID: 24018639
Microcirculatory dysfunction is correlated with increased mortality among septic patients and is believed to be a major contributor to the development of acute kidney injury (AKI). Rolipram, a selective phosphodiesterase...
5.
Wang Z, Holthoff J, Seely K, Pathak E, Spencer 3rd H, Gokden N, et al.
Am J Pathol
. 2011 Nov;
180(2):505-16.
PMID: 22119717
Acute kidney injury is a frequent and serious complication of sepsis. To better understand the development of sepsis-induced acute kidney injury, we performed the first time-dependent studies to document changes...
6.
Holthoff J, Wang Z, Seely K, Gokden N, Mayeux P
Kidney Int
. 2011 Oct;
81(4):370-8.
PMID: 21975863
The mortality rate of patients who develop acute kidney injury during sepsis nearly doubles. The effectiveness of therapy is hampered because it is usually initiated only after the onset of...
7.
Myers C, Berner G, Holthoff J, Martinez-Fonts K, Harper J, Alford S, et al.
PLoS One
. 2011 Jun;
6(6):e20847.
PMID: 21673966
In eukaryotic cells, the highly conserved FACT (FAcilitates Chromatin Transcription) complex plays important roles in several chromatin-based processes including transcription initiation and elongation. During transcription elongation, the FACT complex interacts...
8.
Seely K, Holthoff J, Burns S, Wang Z, Thakali K, Gokden N, et al.
Am J Physiol Renal Physiol
. 2011 Apr;
301(1):F209-17.
PMID: 21511700
Sepsis is a leading cause of acute kidney injury (AKI) and mortality in children. Understanding the development of pediatric sepsis and its effects on the kidney are critical in uncovering...
9.
Holthoff J, Woodling K, Doerge D, Burns S, Hinson J, Mayeux P
Biochem Pharmacol
. 2010 Jul;
80(8):1260-5.
PMID: 20599800
Oxidant damage from reactive oxygen species (ROS) and reactive nitrogen species (RNS) is a major contributor to the cellular damage seen in numerous types of renal injury. Resveratrol (trans-3,4',5-trihydroxystilbene) is...
10.
Wu L, Tiwari M, Messer K, Holthoff J, Gokden N, Brock R, et al.
Am J Physiol Renal Physiol
. 2006 Aug;
292(1):F261-8.
PMID: 16926442
The mortality rate for septic patients with acute renal failure is extremely high. Since sepsis is often caused by lipopolysaccharide (LPS), a model of LPS challenge was used to study...