Joseph G Wettstein
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Explore the profile of Joseph G Wettstein including associated specialties, affiliations and a list of published articles.
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42
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2214
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Recent Articles
11.
Michalon A, Bruns A, Risterucci C, Honer M, Ballard T, Ozmen L, et al.
Biol Psychiatry
. 2013 Aug;
75(3):189-97.
PMID: 23910948
Background: Fragile X syndrome (FXS) is the most common genetic cause for intellectual disability. Fmr1 knockout (KO) mice are an established model of FXS. Chronic pharmacological inhibition of metabotropic glutamate...
12.
Martinez-Cue C, Martinez P, Rueda N, Vidal R, Garcia S, Vidal V, et al.
J Neurosci
. 2013 Mar;
33(9):3953-66.
PMID: 23447605
Down syndrome (DS) is associated with neurological complications, including cognitive deficits that lead to impairment in intellectual functioning. Increased GABA-mediated inhibition has been proposed as a mechanism underlying deficient cognition...
13.
Morairty S, Revel F, Malherbe P, Moreau J, Valladao D, Wettstein J, et al.
PLoS One
. 2012 Jul;
7(7):e39131.
PMID: 22768296
The hypocretin (orexin) system is involved in sleep/wake regulation, and antagonists of both hypocretin receptor type 1 (HCRTR1) and/or HCRTR2 are considered to be potential hypnotic medications. It is currently...
14.
Revel F, Meyer C, Bradaia A, Jeanneau K, Calcagno E, Andre C, et al.
Neuropsychopharmacology
. 2012 Jul;
37(12):2580-92.
PMID: 22763617
Trace amines (TAs) such as β-phenylethylamine, p-tyramine, or tryptamine are biogenic amines found in the brain at low concentrations that have been implicated in various neuropsychiatric disorders like schizophrenia, depression,...
15.
Revel F, Moreau J, Gainetdinov R, Ferragud A, Velazquez-Sanchez C, Sotnikova T, et al.
Biol Psychiatry
. 2012 Jun;
72(11):934-42.
PMID: 22705041
Background: Trace amines, compounds structurally related to classical biogenic amines, represent endogenous ligands of the trace amine-associated receptor 1 (TAAR1). Because trace amines also influence the activity of other targets,...
16.
Michalon A, Sidorov M, Ballard T, Ozmen L, Spooren W, Wettstein J, et al.
Neuron
. 2012 Apr;
74(1):49-56.
PMID: 22500629
Fragile X syndrome (FXS) is the most common form of inherited intellectual disability. Previous studies have implicated mGlu5 in the pathogenesis of the disease, but a crucial unanswered question is...
17.
Prinssen E, Nicolas L, Klein S, Grundschober C, Lopez-Lopez C, Kessler M, et al.
Eur Neuropsychopharmacol
. 2011 Dec;
22(6):441-51.
PMID: 22153786
Functional magnetic resonance imaging (fMRI) has become an important method in clinical psychiatry research whereas there are still only few comparable preclinical investigations. Herein, we report that fMRI in rats...
18.
Alberati D, Moreau J, Lengyel J, Hauser N, Mory R, Borroni E, et al.
Neuropharmacology
. 2011 Dec;
62(2):1152-61.
PMID: 22138164
Dysfunctional N-methyl-d-aspartate (NMDA) receptor neurotransmission has been implicated in the pathophysiology of schizophrenia. It is thought that this abnormal functioning can be corrected by increasing availability of the NMDA co-agonist...
19.
Nic Dhonnchadha B, Pinard E, Alberati D, Wettstein J, Spealman R, Kantak K
Drug Alcohol Depend
. 2011 Oct;
122(1-2):119-26.
PMID: 21992874
Background: Combining extinction training with cognitive-enhancing pharmacotherapy represents a novel strategy for improving the efficacy of exposure therapy for drug relapse prevention. We investigated if the selective glycine transporter-1 (GlyT-1)...
20.
Kessler M, Debilly S, Schoppenthau S, Bielser T, Bruns A, Kunnecke B, et al.
Eur Neuropsychopharmacol
. 2011 Aug;
22(3):222-30.
PMID: 21856130
Unconditioned fear plays an important yet poorly understood role in anxiety disorders, and only few neuroimaging studies have focused on evaluating the underlying neuronal mechanisms. In rodents the predator odor...