Joseph F Solus
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Explore the profile of Joseph F Solus including associated specialties, affiliations and a list of published articles.
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34
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795
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Recent Articles
1.
ONeill M, Yang T, Laudeman J, Calandranis M, Harvey M, Solus J, et al.
Nat Commun
. 2024 Sep;
15(1):8320.
PMID: 39333091
Interpreting the clinical significance of putative splice-altering variants outside canonical splice sites remains difficult without time-intensive experimental studies. To address this, we introduce Parallel Splice Effect Sequencing (ParSE-seq), a multiplexed...
2.
Ma J, ONeill M, Richardson E, Thomson K, Ingles J, Muhammad A, et al.
Circ Genom Precis Med
. 2024 Jul;
17(4):e004569.
PMID: 38953211
Background: Brugada syndrome is an inheritable arrhythmia condition that is associated with rare, loss-of-function variants in . Interpreting the pathogenicity of missense variants is challenging, and ≈79% of missense variants...
3.
Wada Y, Wang L, Hall L, Yang T, Short L, Solus J, et al.
Cardiovasc Res
. 2024 Mar;
120(7):735-744.
PMID: 38442735
Aims: While variants in KCNQ1 are the commonest cause of the congenital long QT syndrome, we and others find only a small IKs in cardiomyocytes from human-induced pluripotent stem cells...
4.
Ma J, ONeill M, Richardson E, Thomson K, Ingles J, Muhammad A, et al.
medRxiv
. 2024 Jan;
PMID: 38196587
Brugada Syndrome (BrS) is an inheritable arrhythmia condition that is associated with rare, loss-of-function variants in the cardiac sodium channel gene, . Interpreting the pathogenicity of missense variants is challenging...
5.
ONeill M, Chen S, Rumping L, Johnson R, van Slegtenhorst M, Glazer A, et al.
Heart Rhythm
. 2023 May;
20(8):1158-1166.
PMID: 37164047
Background: Truncating variants in filamin C (FLNC) can cause arrhythmogenic cardiomyopathy (ACM) through haploinsufficiency. Noncanonical splice-altering variants may contribute to this phenotype. Objective: The purpose of this study was to...
6.
ONeill M, Muhammad A, Li B, Wada Y, Hall L, Solus J, et al.
Genet Med
. 2022 Mar;
24(6):1238-1248.
PMID: 35305865
Purpose: Up to 30% of patients with Brugada syndrome (BrS) carry loss-of-function (LoF) variants in the cardiac sodium channel gene SCN5A encoding for the protein Na1.5. Recent studies suggested that...
7.
Ormseth M, Solus J, Sheng Q, Chen S, Ye F, Wu Q, et al.
Clin Rheumatol
. 2021 Jan;
40(6):2211-2219.
PMID: 33389220
Objective: MicroRNAs (miRNAs) regulate gene expression and are disease biomarkers. Rheumatoid arthritis (RA) patients have accelerated atherosclerosis leading to excess cardiovascular morbidity and mortality, but traditional risk factors for cardiovascular...
8.
Ormseth M, Solus J, Sheng Q, Ye F, Song H, Wu Q, et al.
ACR Open Rheumatol
. 2020 Jan;
2(2):97-105.
PMID: 31913579
Objective: Small RNA (sRNA) sequencing has revealed new sRNA classes beyond microRNAs (miRNAs). These sRNAs can regulate genes and act as biomarkers. The aim of this study was to determine...
9.
Ormseth M, Solus J, Sheng Q, Ye F, Wu Q, Guo Y, et al.
J Rheumatol
. 2019 May;
47(2):188-196.
PMID: 31092710
Objective: MicroRNA (miRNA) are short noncoding RNA that regulate genes and are both biomarkers and mediators of disease. We used small RNA (sRNA) sequencing and machine learning methodology to develop...
10.
Rogers A, Solus J, Hunninghake G, Baron R, Meyer N, Janz D, et al.
Am J Respir Crit Care Med
. 2018 Jul;
198(10):1342-1345.
PMID: 30025215
No abstract available.