Joseph DeSimone
Overview
Explore the profile of Joseph DeSimone including associated specialties, affiliations and a list of published articles.
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58
Citations
1226
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Recent Articles
1.
Che R, Panah M, Mirani B, Knowles K, Ostapovich A, Majumdar D, et al.
bioRxiv
. 2024 Oct;
PMID: 39386709
Despite critical roles in diseases, human pathways acting on strictly nuclear non-coding RNAs have been refractory to forward genetics. To enable their forward genetic discovery, we developed a single-cell approach...
2.
Kaliki S, Vempuluru V, Bakal K, Dorji S, Tanna V, Shields C, et al.
Retina
. 2024 Aug;
44(12):2105-2115.
PMID: 39151183
Purpose: To evaluate high-risk histopathological features following primary enucleation of eyes with retinoblastoma and assess the patient outcomes across continents. Methods: A retrospective study of 1,426 primarily enucleated retinoblastoma eyes...
3.
Hagan C, Bloomquist C, Kim I, Knape N, Byrne J, Tu L, et al.
Acta Biomater
. 2022 Jun;
148:163-170.
PMID: 35724920
Brachytherapy, which is the placement of radioactive seeds directly into tissue such as the prostate, is an important curative treatment for prostate cancer. By delivering a high dose of radiation...
4.
Hagan 4th C, Bloomquist C, Warner S, Knape N, Kim I, Foley H, et al.
J Control Release
. 2022 Feb;
344:147-156.
PMID: 35217100
Surgery is an important treatment for cancer; however, local recurrence following macroscopically-complete resection is common and a significant cause of morbidity and mortality. Systemic chemotherapy is often employed as an...
5.
Soares R, Huang C, Boucher N, Aggarwal N, Fernando R, Hinkle J, et al.
Retina
. 2022 Feb;
42(4):607-615.
PMID: 35174800
Purpose: To characterize how community mobility patterns across the United States correlate with local changes in retina visits during the pandemic. Methods: Outpatient retina clinic visits were linked to population...
6.
Molokie R, DeSimone J, Lavelle D
Semin Hematol
. 2021 Jan;
58(1):10-14.
PMID: 33509438
Human hemoglobin switching describes the highly regulated, sequential expression of the 5 β-like globin genes (HBE, HBG2, HBG1, HBD and HBB) of the human β-globin gene complex. The sequential activation...
7.
Gulati A, Pomeranz C, Qamar Z, Thomas S, Frisch D, George G, et al.
Am J Med Sci
. 2020 Jul;
360(1):5-34.
PMID: 32620220
Since December 2019, the global pandemic caused by the highly infectious novel coronavirus 2019-nCoV (COVID-19) has been rapidly spreading. As of April 2020, the outbreak has spread to over 210...
8.
Rivers A, Vaitkus K, Jagadeeswaran R, Ruiz M, Ibanez V, Ciceri F, et al.
Exp Hematol
. 2018 Aug;
67:60-64.e2.
PMID: 30125603
Increased levels of fetal hemoglobin (HbF) lessen the severity of symptoms and increase the life span of patients with sickle cell disease (SCD). More effective strategies to increase HbF are...
9.
Wells S, DeSimone J
Angew Chem Int Ed Engl
. 2018 May;
40(3):518-527.
PMID: 29712034
CO is a good solvent for many substances when compressed into its liquid or supercritical fluid state. Above the critical temperature and critical pressure (T =31 °C, P =73.8 bar,...
10.
Coffman J, Metz S, Brackbill A, Paul M, Miley M, DeSimone J, et al.
Bioconjug Chem
. 2018 Apr;
29(5):1544-1552.
PMID: 29701995
The dengue virus (DENV) causes over 350 million infections, resulting in ∼25,000 deaths per year globally. An effective dengue vaccine requires generation of strong and balanced neutralizing antibodies against all...