Jose M Lluch
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Explore the profile of Jose M Lluch including associated specialties, affiliations and a list of published articles.
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117
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538
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Recent Articles
1.
Perez-Sanchez A, Curutchet C, Gonzalez-Lafont A, Lluch J
Protein Sci
. 2024 Dec;
34(1):e70001.
PMID: 39720902
Cyclooxygenase-2 (COX-2) plays a crucial role in inflammation and has been implicated in cancer development. Understanding the behavior of COX-2 in different cellular contexts is essential for developing targeted therapeutic...
2.
Gelabert R, Moreno M, Lluch J
ACS Omega
. 2024 Oct;
9(40):41968-41977.
PMID: 39398148
Numerical simulations of the absorption bands of photoswitch --tetrafluoroazobenzene in DMSO solution under one-, two-, and three-photon absorption conditions combined with the analysis of the behavior of transition probability under...
3.
Sortino R, Cunquero M, Castro-Olvera G, Gelabert R, Moreno M, Riefolo F, et al.
Angew Chem Int Ed Engl
. 2023 Oct;
62(51):e202311181.
PMID: 37823736
To interrogate neural circuits and crack their codes, in vivo brain activity imaging must be combined with spatiotemporally precise stimulation in three dimensions using genetic or pharmacological specificity. This challenge...
4.
Zhuravlev A, Cruz A, Aksenov V, Golovanov A, Lluch J, Kuhn H, et al.
Molecules
. 2023 Jul;
28(14).
PMID: 37513289
Mammalian 15-lipoxygenases (ALOX15) are lipid peroxidizing enzymes that exhibit variable functionality in different cancer and inflammation models. The pathophysiological role of linoleic acid- and arachidonic acid-derived ALOX15 metabolites rendered this...
5.
Kakularam K, Canyelles-Nino M, Chen X, Lluch J, Gonzalez-Lafont A, Kuhn H
Int J Mol Sci
. 2023 Jun;
24(12).
PMID: 37373195
The arachidonic acid lipoxygenase 15B (ALOX15B) orthologs of men and mice form different reaction products when arachidonic acid is used as the substrate. Tyr603Asp+His604Val double mutation in mouse arachidonic acid...
6.
Canyelles-Nino M, Gonzalez-Lafont A, Lluch J
Int J Mol Sci
. 2023 Apr;
24(7).
PMID: 37047037
lipoxygenase 12 (hALOX12) catalyzes the conversion of docosahexaenoic acid (DHA) into mainly 14S-hydroperoxy-4Z,7Z,10Z,12E,16Z,19Z-docosahexaenoic acid (14S-H(p)DHA). This hydroperoxidation reaction is followed by an epoxidation and hydrolysis process that finally leads to...
7.
Gelabert R, Moreno M, Lluch J
Int J Mol Sci
. 2023 Jan;
24(1).
PMID: 36613468
Simulations based on molecular dynamics coupled to excitation energy calculations were used to generate simulated absorption spectra for a family of halide derivatives of azobenzene, a family of photoswitch molecules...
8.
Moreno M, Lluch J, Gelabert R
Int J Mol Sci
. 2022 Aug;
23(15).
PMID: 35955820
In order to theoretically design multi-state photoswitches with specific properties, an exhaustive computational study is first carried out for an azobenzene dimer that has been recently synthesized and experimentally studied....
9.
Garcia-Viloca M, Bayascas J, Lluch J, Gonzalez-Lafont A
ACS Omega
. 2022 Aug;
7(29):25186-25199.
PMID: 35910176
The 3-phosphoinositide-dependent protein kinase 1 (PDK1) K465E mutant kinase can still activate protein kinase B (PKB) at the membrane in a phosphatidylinositol-3,4,5-trisphosphate (PIP, PtdIns(3,4,5)P) independent manner. To understand this new...
10.
Suner-Rubio A, Cebrian-Prats A, Gonzalez-Lafont A, Lluch J
RSC Adv
. 2022 May;
10(2):986-997.
PMID: 35494430
Cyclooxygenases (COXs) are the enzymes responsible for the biosynthesis of prostaglandins, eicosanoids that play a major role in many physiological processes. Particularly, prostaglandins are known to trigger inflammation, and COX-2,...