Jose M Inacio
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Explore the profile of Jose M Inacio including associated specialties, affiliations and a list of published articles.
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15
Citations
78
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Recent Articles
1.
Inacio J, Cristo F, Pinheiro M, Vasques-Novoa F, Saraiva F, Nunes M, et al.
Biomedicines
. 2023 Aug;
11(8).
PMID: 37626628
Heart failure with preserved ejection fraction (HFpEF) represents a global health challenge, with limited therapies proven to enhance patient outcomes. This makes the elucidation of disease mechanisms and the identification...
2.
von Gilsa Lopes J, Inacio J, Marques S, Anez S, Belo J
Curr Stem Cell Res Ther
. 2023 May;
PMID: 37194232
Background: Dand5 encodes a protein that acts as an antagonist to Nodal/TGF-β and Wnt pathways. A mouse knockout (KO) model has shown that this molecule is associated with left-right asymmetry...
3.
Inacio J, Nunes M, Almeida M, Cristo F, Anjos R, Belo J
Cells
. 2023 Feb;
12(4).
PMID: 36831187
(1) Background: The contribution of gene-specific variants for congenital heart disease, one of the most common congenital disabilities, is still far from our complete understanding. Here, we applied a disease...
4.
Ganapathi M, Buchovecky C, Cristo F, Ahimaz P, Ruzal-Shapiro C, Wou K, et al.
Cold Spring Harb Mol Case Stud
. 2022 Oct;
8(7).
PMID: 36316122
The majority of heterotaxy cases do not obtain a molecular diagnosis, although pathogenic variants in more than 50 genes are known to cause heterotaxy. A heterozygous missense variant in ,...
5.
Bonet F, Inacio J, Bover O, Anez S, Belo J
Front Genet
. 2022 Feb;
13:836694.
PMID: 35222551
The collagen- and calcium-binding EGF-like domains 1 (CCBE1) is a secreted protein extensively described as indispensable for lymphangiogenesis during development enhancing VEGF-C signaling. In human patients, mutations in have been...
6.
Inacio J, Almeida M, Cristo F, Belo J
Stem Cell Res
. 2019 Dec;
42:101677.
PMID: 31869685
Human induced pluripotent stem cells (hiPSCs) from individual patient basis are considered a powerful resource to model human diseases. However, to study complex multigenic diseases such as Congenital Heart Disease,...
7.
Bover O, Justo T, Pereira P, Facucho-Oliveira J, Inacio J, Ramalho J, et al.
PLoS One
. 2018 Oct;
13(10):e0205108.
PMID: 30281646
Understanding the molecular pathways regulating cardiogenesis is crucial for the early diagnosis of heart diseases and improvement of cardiovascular disease. During normal mammalian cardiac development, collagen and calcium-binding EGF domain-1...
8.
Bonet F, Pereira P, Bover O, Marques S, Inacio J, Belo J
Dev Dyn
. 2018 Sep;
247(10):1135-1145.
PMID: 30204931
Background: Proper coronary vasculature development is essential for late-embryonic and adult heart function. The developmental regulation of coronary embryogenesis is complex and includes the coordinated activity of multiple signaling pathways....
9.
Silva M, Gomes-Alves P, Rosa S, Simao D, Inacio J, Peixoto C, et al.
J Biotechnol
. 2018 Aug;
285:6-14.
PMID: 30165116
Collagen and calcium-binding EGF domain-1 (CCBE1) is a secreted protein critical for lymphatic/cardiac vascular development and regeneration. However, the low efficient production of the recombinant full-length CCBE1 (rCCBE1) has been...
10.
Pars S, Cristo F, Inacio J, Rosas G, Carreira I, Melo J, et al.
Stem Cell Res
. 2018 May;
29:202-206.
PMID: 29730570
A DAND5-control human iPSC line was generated from the urinary cells of a phenotypically normal donor. Exfoliated renal epithelial (RE) cells were collected and reprogrammed into iPSCs using Sendai virus...