Jose F Cascalheira
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Explore the profile of Jose F Cascalheira including associated specialties, affiliations and a list of published articles.
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11
Citations
55
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Recent Articles
1.
Adenosine Inhibits Cell Proliferation Differently in Human Astrocytes and in Glioblastoma Cell Lines
Marcelino H, Carvalho T, Tomas J, Teles F, Honorio A, Rosa C, et al.
Neuroscience
. 2021 May;
467:122-133.
PMID: 34033870
Glioblastoma (GBM) is the most common brain primary tumour. Hypoxic regions in GBM are associated to tumour growth. Adenosine accumulates in hypoxic regions and can affect cell proliferation and survival....
2.
Marcelino H, Nogueira V, Santos C, Quelhas P, Carvalho T, Fonseca-Gomes J, et al.
J Neurochem
. 2019 Dec;
153(4):455-467.
PMID: 31811731
Brain adenosine concentrations can reach micromolar concentrations in stressful situations such as stroke, neurodegenerative diseases or hypoxic regions of brain tumours. Adenosine can act by receptor-independent mechanism by reversing the...
3.
Pinto I, Serpa A, Sebastiao A, Cascalheira J
Front Pharmacol
. 2016 May;
7:103.
PMID: 27148059
Both adenosine A1 receptor and cGMP inhibit synaptic transmission at the hippocampus and recently it was found that A1 receptor increased cGMP levels in hippocampus, but the role of cGMP...
4.
Serpa A, Pinto I, Bernardino L, Cascalheira J
Neurochem Int
. 2015 Jun;
87:106-9.
PMID: 26065937
Both adenosine A1 and cannabinoid CB1 receptors trigger similar transduction pathways and protect against neurotoxic insults at the hippocampus, but their combined neuroprotective potential has not been investigated. We set...
5.
Serpa A, Correia S, Ribeiro J, Sebastiao A, Cascalheira J
Biomed Res Int
. 2015 Feb;
2015:872684.
PMID: 25667928
Adenosine A1 and cannabinoid CB1 receptors are highly expressed in hippocampus where they trigger similar transduction pathways. We investigated how the combined acute activation of A1 and CB1 receptors modulates...
6.
Cascalheira J, Goncalves M, Barroso M, Castro R, Palmeira M, Serpa A, et al.
Ann Clin Biochem
. 2014 Nov;
52(Pt 4):448-55.
PMID: 25395544
Background: Decreased serum concentrations of vitamin B12 are associated with Alzheimer's type dementia. The transcobalamin II gene (TCN2) 776C → G polymorphism affects transcobalamin II function as a carrier of...
7.
Serpa A, Sebastiao A, Cascalheira J
Eur J Pharmacol
. 2014 Oct;
744:83-90.
PMID: 25300679
Adenosine A1 receptor is highly expressed in hippocampus where it inhibits neurotransmitter release and has neuroprotective activity. Similar actions are obtained by increasing cGMP concentration, but a clear link between...
8.
Aguilar P, Nunes C, Cascalheira J, Dias-Cabral A
J Chromatogr A
. 2011 Oct;
1218(46):8322-32.
PMID: 21963180
In the present study, Angiotensin I (Ang I) will be used as model peptide to assess on-column alteration of conformation phenomena. Adsorptive behavior of Ang I on various commercial hydrophobic...
9.
Cascalheira J, Joao S, Pinhancos S, Castro R, Palmeira M, Almeida S, et al.
Clin Biochem
. 2009 Feb;
42(9):783-90.
PMID: 19232336
Objectives: To study the interplay between serum concentrations of homocysteine, steroid hormones and vitamins B and mutations in 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, in association to Alzheimer's type dementia (ATD). Design...
10.
Cascalheira J, Parreira M, Viegas A, Faria M, Domingues F
Ann Nutr Metab
. 2008 Oct;
53(1):67-74.
PMID: 18827476
Background/aim: High serum levels of homocysteine and cortisol are independent risk factors for several pathologies and their levels can be regulated by some vitamins. Since the relationship between serum concentrations...