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Jose Donato

Explore the profile of Jose Donato including associated specialties, affiliations and a list of published articles. Areas
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Articles 14
Citations 137
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Recent Articles
1.
Saenz de Miera C, Bellefontaine N, Silveira M, Fortin C, Zampieri T, Donato J, et al.
bioRxiv . 2025 Feb; PMID: 39975315
Pubertal development is tightly regulated by energy balance. The crosstalk between metabolism and reproduction is orchestrated by complex neural networks and leptin action in the hypothalamus plays a critical role....
2.
Velloso L, Donato J
J Obes Metab Syndr . 2024 Dec; 33(4):302-313. PMID: 39639711
While inflammation is a crucial response in injury repair and tissue regeneration, chronic inflammation is a prevalent feature in various chronic, non-communicable diseases such as obesity, diabetes, and cancer and...
3.
Tavares M, Frazao R, Donato J
J Endocrinol . 2022 Nov; 256(1). PMID: 36327147
Growth hormone (GH) is secreted by the anterior pituitary gland and plays a key role in controlling tissue and body growth. While basal GH secretion is considerably reduced along adulthood...
4.
Gusmao D, de Sousa M, Tavares M, Donato J
Endocrinology . 2022 Sep; 163(11). PMID: 36099517
Growth hormone (GH) secretion is controlled by short and long negative feedback loops. In this regard, both GH (short-loop feedback) and insulin-like growth factor 1 (IGF-1; long-loop feedback) can target...
5.
de Souza G, Chaves F, Silva J, Pedroso J, Metzger M, Frazao R, et al.
J Endocrinol . 2022 Aug; 255(2):75-90. PMID: 35993424
Recent studies indicated an important role of connexins, gap junction proteins, in the regulation of metabolism. However, most of these studies focused on the glial expression of connexins, whereas the...
6.
Dos Santos W, Wasinski F, Tavares M, Campos A, Elias C, List E, et al.
Endocrinology . 2022 Jul; 163(8). PMID: 35803590
Growth hormone (GH) acts in several hypothalamic neuronal populations to modulate metabolism and the autoregulation of GH secretion via negative-feedback loops. However, few studies have investigated whether GH receptor (GHR)...
7.
Chaves F, Wasinski F, Tavares M, Mansano N, Frazao R, Gusmao D, et al.
Endocrinology . 2022 Apr; 163(5). PMID: 35395079
Hypophysiotropic somatostatin (SST) neurons in the periventricular hypothalamic area express growth hormone (GH) receptor (GHR) and are frequently considered as the key neuronal population that mediates the negative feedback loop...
8.
de Brito Monteiro L, Prodonoff J, de Aguiar C, Correa-da-Silva F, Castoldi A, van Teijlingen Bakker N, et al.
Diabetes . 2022 Apr; 71(7):1546-1561. PMID: 35377454
Obesity is a major concern for global health care systems. Systemic low-grade inflammation in obesity is a major risk factor for insulin resistance. Leptin is an adipokine secreted by the...
9.
Quaresma P, Wasinski F, Mansano N, Furigo I, Teixeira P, Gusmao D, et al.
Endocrinology . 2021 Aug; 162(11). PMID: 34402859
Previous studies indicate that leptin receptor (LepR) expression in GABAergic neurons is necessary for the biological effects of leptin. However, it is not clear whether LepR expression only in GABAergic...
10.
Wasinski F, Barrile F, Pedroso J, Quaresma P, Dos Santos W, List E, et al.
Endocrinology . 2021 May; 162(7). PMID: 33972988
Ghrelin stimulates both GH secretion and food intake. The orexigenic action of ghrelin is mainly mediated by neurons that coexpress agouti-related protein (AgRP) and neuropeptide Y (NPY) in the arcuate...