Jose A Montero Santamaria
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Explore the profile of Jose A Montero Santamaria including associated specialties, affiliations and a list of published articles.
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11
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91
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Recent Articles
1.
PET Quantification in Healthy Humans of Cyclooxygenase-2, a Potential Biomarker of Neuroinflammation
Yan X, Noergaard M, Morse C, Liow J, Hong J, Greve D, et al.
J Nucl Med
. 2025 Jan;
66(3):398-404.
PMID: 39848764
Cyclooxygenase-2 (COX-2) is present in a healthy brain at low densities but can be markedly upregulated by excitatory input and by inflammogens. This study evaluated the sensitivity of the PET...
2.
Yan X, Simeon F, Liow J, Morse C, Jana S, Montero Santamaria J, et al.
J Cereb Blood Flow Metab
. 2024 Dec;
45(2):365-372.
PMID: 39654356
[F]SF51 is a novel radioligand for imaging translocator protein 18 kDa (TSPO) that previously displayed excellent imaging properties in nonhuman primates. This study assessed its performance in human brain and...
3.
Ghazanfari N, Liow J, Kim M, Cureton R, Lee A, Knoer C, et al.
J Nucl Med
. 2024 Nov;
66(1):117-122.
PMID: 39542698
Our laboratory recently developed [C]PS13 as a PET radioligand to selectively measure cyclooxygenase-1 (COX-1). The cyclooxygenase enzyme family converts arachidonic acid into prostaglandins and thromboxanes, which mediate inflammation. The total...
4.
Yan X, Simeon F, Liow J, Morse C, Montero Santamaria J, Jenkins M, et al.
Eur J Nucl Med Mol Imaging
. 2023 May;
50(10):2962-2970.
PMID: 37249618
Purpose: [F]SF51 was previously found to have high binding affinity and selectivity for 18 kDa translocator protein (TSPO) in mouse brain. This study sought to assess the ability of [F]SF51...
5.
Altomonte S, Yan X, Morse C, Liow J, Jenkins M, Montero Santamaria J, et al.
ACS Pharmacol Transl Sci
. 2023 Apr;
6(4):614-632.
PMID: 37082755
[C] has been advocated as a radioligand for colony-stimulating factor 1 receptor (CSF1R) with the potential for imaging neuroinflammation in human subjects with positron emission tomography (PET). This study sought...
6.
Kim M, Juarez Anaya F, Manly L, Lee J, Hong J, Shrestha S, et al.
J Nucl Med
. 2022 Jul;
64(1):159-164.
PMID: 35798558
Both cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) convert arachidonic acid to prostaglandin H, which has proinflammatory effects. The recently developed PET radioligand C-PS13 has excellent in vivo selectivity for COX-1 over...
7.
Wakabayashi Y, Stenkrona P, Arakawa R, Yan X, Van Buskirk M, Jenkins M, et al.
J Nucl Med
. 2022 Jun;
63(12):1919-1924.
PMID: 35772961
Phosphodiesterase-4 (PDE4), which metabolizes the second messenger cyclic adenosine monophosphate (cAMP), has 4 isozymes: PDE4A, PDE4B, PDE4C, and PDE4D. PDE4B and PDE4D have the highest expression in the brain and...
8.
Lee J, Simeon F, Liow J, Morse C, Gladding R, Montero Santamaria J, et al.
J Nucl Med
. 2022 Jan;
63(8):1252-1258.
PMID: 35027372
Because of its excellent ratio of specific to nondisplaceable uptake, the radioligand C-ER176 can successfully image 18-kDa translocator protein (TSPO), a biomarker of inflammation, in the human brain and accurately...
9.
Lee J, Veronese M, Liow J, Morse C, Montero Santamaria J, Haskali M, et al.
EJNMMI Res
. 2021 Apr;
11(1):35.
PMID: 33796956
Background: Previous studies found that the positron emission tomography (PET) radioligand [F]LSN3316612 accurately quantified O-GlcNAcase in human brain using a two-tissue compartment model (2TCM). This study sought to assess kinetic...
10.
Kim M, Lee J, Juarez Anaya F, Hong J, Miller W, Telu S, et al.
Eur J Nucl Med Mol Imaging
. 2020 May;
47(13):3143-3151.
PMID: 32399622
Purpose: This study assessed whether the newly developed PET radioligand [C]PS13, which has shown excellent in vivo selectivity in previous animal studies, could be used to quantify constitutive levels of...