Jose-Juan Lopez-Rubio
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Explore the profile of Jose-Juan Lopez-Rubio including associated specialties, affiliations and a list of published articles.
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25
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1215
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Recent Articles
11.
Lee M, Lindner S, Lopez-Rubio J, Llinas M
Brief Funct Genomics
. 2019 Aug;
18(5):281-289.
PMID: 31365053
CRISPR/Cas9 approaches are revolutionizing our ability to perform functional genomics across a wide range of organisms, including the Plasmodium parasites that cause malaria. The ability to deliver single point mutations,...
12.
Dorin-Semblat D, Tetard M, Claes A, Semblat J, Dechavanne S, Fourati Z, et al.
PLoS Biol
. 2019 Jun;
17(6):e3000308.
PMID: 31181082
Plasmodium falciparum is the main cause of disease and death from malaria. P. falciparum virulence resides in the ability of infected erythrocytes (IEs) to sequester in various tissues through the...
13.
Neveu G, Dupuy F, Ladli M, Barbieri D, Naissant B, Richard C, et al.
Sci Rep
. 2018 Dec;
8(1):17886.
PMID: 30552367
Plasmodium falciparum gametocytes, the sexual stages responsible for malaria parasite transmission, develop in the human bone marrow parenchyma in proximity to the erythroblastic islands. Yet, mechanisms underlying gametocytes interactions with...
14.
Chan S, Frasch A, Mandava C, Chng J, Del Pilar Quintana M, Vesterlund M, et al.
Nat Microbiol
. 2017 May;
2:17068.
PMID: 28481333
Pregnancy-associated malaria commonly involves the binding of Plasmodium falciparum-infected erythrocytes to placental chondroitin sulfate A (CSA) through the PfEMP1-VAR2CSA protein. VAR2CSA is translationally repressed by an upstream open reading frame....
15.
Bandje K, Naissant B, Bigey P, Lohezic M, Vayssieres M, Blaud M, et al.
Malar J
. 2016 May;
15:248.
PMID: 27129434
Background: The asexual intra-erythrocytic multiplication of the malaria parasite Plasmodium falciparum is regulated by various molecular mechanisms. In eukaryotic cells, protein kinases are known to play key roles in cell...
16.
Sollelis L, Ghorbal M, Macpherson C, Martins R, Kuk N, Crobu L, et al.
Cell Microbiol
. 2015 May;
17(10):1405-12.
PMID: 25939677
Protozoan pathogens that cause leishmaniasis in humans are relatively refractory to genetic manipulation. In this work, we implemented the CRISPR-Cas9 system in Leishmania parasites and demonstrated its efficient use for...
17.
Mbengue A, Bhattacharjee S, Pandharkar T, Liu H, Estiu G, Stahelin R, et al.
Nature
. 2015 Apr;
520(7549):683-7.
PMID: 25874676
Artemisinins are the cornerstone of anti-malarial drugs. Emergence and spread of resistance to them raises risk of wiping out recent gains achieved in reducing worldwide malaria burden and threatens future...
18.
Nacer A, Claes A, Roberts A, Scheidig-Benatar C, Sakamoto H, Ghorbal M, et al.
Cell Microbiol
. 2015 Feb;
17(8):1205-16.
PMID: 25703704
Plasmodium falciparum virulence is linked to its ability to sequester in post-capillary venules in the human host. Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is the main variant surface antigen...
19.
Ghorbal M, Gorman M, Macpherson C, Martins R, Scherf A, Lopez-Rubio J
Nat Biotechnol
. 2014 Jun;
32(8):819-21.
PMID: 24880488
Genome manipulation in the malaria parasite Plasmodium falciparum remains largely intractable and improved genomic tools are needed to further understand pathogenesis and drug resistance. We demonstrated the CRISPR-Cas9 system for...
20.
Siegel T, Hon C, Zhang Q, Lopez-Rubio J, Scheidig-Benatar C, Martins R, et al.
BMC Genomics
. 2014 Feb;
15:150.
PMID: 24559473
Background: Advances in high-throughput sequencing have led to the discovery of widespread transcription of natural antisense transcripts (NATs) in a large number of organisms, where these transcripts have been shown...