Joscelyn C Mejias
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Explore the profile of Joscelyn C Mejias including associated specialties, affiliations and a list of published articles.
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10
Citations
159
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Recent Articles
1.
Yang B, Rutkowski N, Ruta A, Gray-Gaillard E, Maestas D, Kelly S, et al.
bioRxiv
. 2025 Jan;
PMID: 39868312
Significance Statement: The foreign body response to implants leads to chronic inflammation and fibrosis that can be highly variable in the general patient population. Here, we demonstrate that gut dysbiosis...
2.
Han J, Cherry C, Mejias J, Krishnan K, Ruta A, Maestas Jr D, et al.
Adv Mater
. 2023 Dec;
36(43):e2310476.
PMID: 38087458
Aging is associated with immunological changes that compromise response to infections and vaccines, exacerbate inflammatory diseases and can potentially mitigate tissue repair. Even so, age-related changes to the immune response...
3.
Sommerfeld S, Zhou X, Mejias J, Oh B, Maestas Jr D, Furtmuller G, et al.
Biomater Sci
. 2023 May;
11(11):4022-4031.
PMID: 37129566
Vascularized composite allotransplantation (VCA) is a restorative option for patients suffering from severe tissue defects not amenable to conventional reconstruction. However, the toxicities associated with life-long multidrug immunosuppression to enable...
4.
Cherry C, Andorko J, Krishnan K, Mejias J, Nguyen H, Stivers K, et al.
Geroscience
. 2023 Apr;
45(4):2559-2587.
PMID: 37079217
Cellular senescence is a state of permanent growth arrest that plays an important role in wound healing, tissue fibrosis, and tumor suppression. Despite senescent cells' (SnCs) pathological role and therapeutic...
5.
Maestas Jr D, Chung L, Han J, Wang X, Sommerfeld S, Kelly S, et al.
Proc Natl Acad Sci U S A
. 2023 Feb;
120(8):e2211703120.
PMID: 36780522
The immune system is increasingly recognized as an important regulator of tissue repair. We developed a regenerative immunotherapy from the helminth soluble egg antigen (SEA) to stimulate production of interleukin...
6.
Pena A, Sommerfeld S, Anderson A, Han J, Maestas Jr D, Mejias J, et al.
Arthritis Res Ther
. 2022 Sep;
24(1):221.
PMID: 36096945
Osteoarthritis (OA) is a degenerative disease associated with cartilage degradation, osteophyte formation, and fibrillation. Autologous Protein Solution (APS), a type of autologous anti-inflammatory orthobiologic, is used for pain management and...
7.
Nelson M, Ghoshal D, Mejias J, Rubio D, Keith E, Roy K
Biomaterials
. 2021 Feb;
270:120683.
PMID: 33556648
The human bone marrow (hBM) is a complex organ critical for hematopoietic and immune homeostasis, and where many cancers metastasize. Understanding the fundamental biology of the hBM in health and...
8.
Mejias J, Nelson M, Liseth O, Roy K
Lab Chip
. 2020 Sep;
20(19):3601-3611.
PMID: 32990704
Development of organoids and microfluidic on-chip models has enabled studies of organ-level disease pathophysiologies in vitro. However, current lung-on-a-chip platforms are primarily monolayer epithelial-endothelial co-cultures, separated by a thin membrane,...
9.
Mejias J, Roy K
J Control Release
. 2019 Nov;
316:393-403.
PMID: 31715279
Although the lung is an obvious target for site-specific delivery of many therapeutics for respiratory airway diseases such as asthma, COPD, and cystic fibrosis, novel strategies are needed to avoid...
10.
Mejias J, Forrest O, Margaroli C, Frey Rubio D, Viera L, Li J, et al.
JCI Insight
. 2019 Oct;
4(23).
PMID: 31661469
Pulmonary drug delivery presents a unique opportunity to target lower airway inflammation, which is often characterized by the massive recruitment of neutrophils from blood. However, specific therapies are lacking modulation...