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Joris van der Veeken

Explore the profile of Joris van der Veeken including associated specialties, affiliations and a list of published articles. Areas
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Articles 20
Citations 3149
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Recent Articles
1.
Leng F, Zhang W, Ramirez R, Leon J, Zhong Y, Hou L, et al.
Immunity . 2022 Aug; 55(8):1354-1369.e8. PMID: 35926508
FoxP3 is an essential transcription factor (TF) for immunologic homeostasis, but how it utilizes the common forkhead DNA-binding domain (DBD) to perform its unique function remains poorly understood. We here...
2.
van der Veeken J, Campbell C, Pritykin Y, Schizas M, Verter J, Hu W, et al.
Immunity . 2022 Jun; 55(7):1173-1184.e7. PMID: 35700740
Regulatory T (Treg) cells expressing the transcription factor Foxp3 are an essential suppressive T cell lineage of dual origin: Foxp3 induction in thymocytes and mature CD4 T cells gives rise...
3.
Zhong Y, Walker S, Pritykin Y, Leslie C, Rudensky A, van der Veeken J
Nat Immunol . 2021 Dec; 23(1):122-134. PMID: 34937932
T cell activation, a key early event in the adaptive immune response, is subject to elaborate transcriptional control. In the present study, we examined how the activities of eight major...
4.
Hu W, Wang Z, Feng Y, Schizas M, Hoyos B, van der Veeken J, et al.
Nat Immunol . 2021 Aug; 22(9):1163-1174. PMID: 34426690
The immunosuppressive function of regulatory T (T) cells is dependent on continuous expression of the transcription factor Foxp3. Foxp3 loss of function or induced ablation of T cells results in...
5.
Pritykin Y, van der Veeken J, Pine A, Zhong Y, Sahin M, Mazutis L, et al.
Mol Cell . 2021 Apr; 81(11):2477-2493.e10. PMID: 33891860
CD8 T cells play an essential role in defense against viral and bacterial infections and in tumor immunity. Deciphering T cell loss of functionality is complicated by the conspicuous heterogeneity...
6.
Campbell C, Marchildon F, Michaels A, Takemoto N, van der Veeken J, Schizas M, et al.
Proc Natl Acad Sci U S A . 2020 Dec; 117(52):33446-33454. PMID: 33318189
Reduced nutrient intake is a widely conserved manifestation of sickness behavior with poorly characterized effects on adaptive immune responses. During infectious challenges, naive T cells encountering their cognate antigen become...
7.
van der Veeken J, Glasner A, Zhong Y, Hu W, Wang Z, Bou-Puerto R, et al.
Immunity . 2020 Nov; 53(5):971-984.e5. PMID: 33176163
Regulatory T (Treg) cell identity is defined by the lineage-specifying transcription factor (TF) Foxp3. Here we examined mechanisms of Foxp3 function by leveraging naturally occurring genetic variation in wild-derived inbred...
8.
Van Ruth S, van der Veeken J, Dekker P, Luning P, Huisman W
Food Res Int . 2020 May; 133:109158. PMID: 32466937
This study examines fraud vulnerability in the food service industry; identifies underlying fraud vulnerability factors; and studies the differences in fraud vulnerability between casual dining restaurants, fine dining restaurants and...
9.
van der Veeken J, Zhong Y, Sharma R, Mazutis L, Dao P, Peer D, et al.
Immunity . 2019 Apr; 50(5):1202-1217.e7. PMID: 31027997
Stable changes in chromatin states and gene expression in cells of the immune system form the basis for memory of infections and other challenges. Here, we used naturally occurring cis-regulatory...
10.
van der Veeken J, Gonzalez A, Cho H, Arvey A, Hemmers S, Leslie C, et al.
Cell . 2016 Aug; 166(4):977-990. PMID: 27499023
Eukaryotic cells can "remember" transient encounters with a wide range of stimuli, inducing lasting states of altered responsiveness. Regulatory T (Treg) cells are a specialized lineage of suppressive CD4 T ...