Jorge Moscat
Overview
Explore the profile of Jorge Moscat including associated specialties, affiliations and a list of published articles.
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Articles
123
Citations
13354
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Recent Articles
1.
Chatterjee S, Linares J, Cid-Diaz T, Duran A, Khan M, Osrodek M, et al.
Nat Commun
. 2024 Nov;
15(1):9755.
PMID: 39567499
Overcoming resistance to therapy is a major challenge in castration-resistant prostate cancer (CRPC). Lineage plasticity towards a neuroendocrine phenotype enables CRPC to adapt and survive targeted therapies. However, the molecular...
2.
Nishimura S, Linares J, LHermitte A, Duran A, Cid-Diaz T, Martinez-Ordonez A, et al.
Mol Cell
. 2024 Oct;
84(23):4660-4676.e10.
PMID: 39423823
Hepatocellular carcinoma (HCC) emerges from chronic inflammation, to which activation of hepatic stellate cells (HSCs) contributes by shaping a pro-tumorigenic microenvironment. Key to this process is p62, whose inactivation leads...
3.
Martinez-Ordonez A, Kinoshita H, Cid-Diaz T, Duran A, Osrodek M, Diaz-Meco M, et al.
STAR Protoc
. 2024 Sep;
5(3):103303.
PMID: 39264806
Applying Opal multiplex immunofluorescence (OMI) to characterize intestinal tissues of genetically engineered mouse models provides an excellent tool for studying complex processes. However, detecting appropriate signals from multiple target molecules...
4.
Kinoshita H, Martinez-Ordonez A, Cid-Diaz T, Han Q, Duran A, Muta Y, et al.
Dev Cell
. 2024 May;
59(15):1972-1987.e8.
PMID: 38815584
The early mechanisms of spontaneous tumor initiation that precede malignancy are largely unknown. We show that reduced aPKC levels correlate with stem cell loss and the induction of revival and...
5.
Muta Y, Linares J, Martinez-Ordonez A, Duran A, Cid-Diaz T, Kinoshita H, et al.
Nat Commun
. 2023 Dec;
14(1):8075.
PMID: 38092754
The metabolic and signaling pathways regulating aggressive mesenchymal colorectal cancer (CRC) initiation and progression through the serrated route are largely unknown. Although relatively well characterized as BRAF mutant cancers, their...
6.
Omatsu M, Nakanishi Y, Iwane K, Aoyama N, Duran A, Muta Y, et al.
Nat Commun
. 2023 Sep;
14(1):5534.
PMID: 37749092
Mesenchymal activation, characterized by dense stromal infiltration of immune and mesenchymal cells, fuels the aggressiveness of colorectal cancers (CRC), driving progression and metastasis. Targetable molecules in the tumor microenvironment (TME)...
7.
Utsumi T, Yamada Y, Diaz-Meco M, Moscat J, Nakanishi Y
J Gastroenterol
. 2023 May;
58(8):705-717.
PMID: 37219625
The serrated neoplasia pathway constitutes an "alternative route" to colorectal cancer (CRC), and sessile serrated lesions with dysplasia (SSLDs) are an intermediate step between sessile serrated lesions (SSLs) and invasive...
8.
Martinez-Ordonez A, Cid-Diaz T, Duran A, Han Q, Moscat J, Diaz-Meco M
STAR Protoc
. 2023 Apr;
4(2):102243.
PMID: 37083323
Imaging organoid culture provides an excellent tool for studying complex diseases such as cancer. However, retaining the morphology of intact organoids for immunolabeling has been challenging. Here, we describe a...
9.
Martinez-Ordonez A, Duran A, Ruiz-Martinez M, Cid-Diaz T, Zhang X, Han Q, et al.
Cancer Cell
. 2022 Dec;
41(2):252-271.e9.
PMID: 36525970
Mesenchymal colorectal cancer (mCRC) is microsatellite stable (MSS), highly desmoplastic, with CD8 T cells excluded to the stromal periphery, resistant to immunotherapy, and driven by low levels of the atypical...
10.
Cid-Diaz T, Lodeiro A, Duran A, Moscat J, Diaz-Meco M
STAR Protoc
. 2022 Aug;
3(3):101635.
PMID: 36035805
Air-liquid organotypic culture models enable the study of the cellular crosstalk in the tumor microenvironment. This 3D assay recapitulates the tumor niche more faithfully than 2D culture systems and represents...