Jordan D Carelli
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Explore the profile of Jordan D Carelli including associated specialties, affiliations and a list of published articles.
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5
Citations
65
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Recent Articles
1.
Craven G, Chu H, Sun J, Carelli J, Coyne B, Chen H, et al.
Nature
. 2024 Nov;
637(8044):205-214.
PMID: 39506119
Somatic alterations in the oncogenic kinase AKT1 have been identified in a broad spectrum of solid tumours. The most common AKT1 alteration replaces Glu17 with Lys (E17K) in the regulatory...
2.
Oltion K, Carelli J, Yang T, See S, Wang H, Kampmann M, et al.
Cell
. 2023 Jan;
186(2):346-362.e17.
PMID: 36638793
Ribosomes frequently stall during mRNA translation, resulting in the context-dependent activation of quality control pathways to maintain proteostasis. However, surveillance mechanisms that specifically respond to stalled ribosomes with an occluded...
3.
Juette M, Carelli J, Rundlet E, Brown A, Shao S, Ferguson A, et al.
Elife
. 2022 Oct;
11.
PMID: 36264623
Rapid and accurate mRNA translation requires efficient codon-dependent delivery of the correct aminoacyl-tRNA (aa-tRNA) to the ribosomal A site. In mammals, this fidelity-determining reaction is facilitated by the GTPase elongation...
4.
Yang T, Cuesta A, Wan X, Craven G, Hirakawa B, Khamphavong P, et al.
Nat Chem Biol
. 2022 May;
18(9):934-941.
PMID: 35590003
The expansion of the target landscape of covalent inhibitors requires the engagement of nucleophiles beyond cysteine. Although the conserved catalytic lysine in protein kinases is an attractive candidate for a...
5.
Carelli J, Sethofer S, Smith G, Miller H, Simard J, Merrick W, et al.
Elife
. 2015 Dec;
4.
PMID: 26651998
Cyclic peptide natural products have evolved to exploit diverse protein targets, many of which control essential cellular processes. Inspired by a series of cyclic peptides with partially elucidated structures, we...