Joon Sig Choi
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Explore the profile of Joon Sig Choi including associated specialties, affiliations and a list of published articles.
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89
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Recent Articles
1.
Le T, Thuy L, Le T, Jin S, Shin S, Lyu A, et al.
J Control Release
. 2025 Feb;
380:1095-1108.
PMID: 39986472
Gene therapy has emerged as a promising approach for treating inner ear disorders, such as hearing loss and balance impairments, which require precise and efficient delivery mechanisms. This study introduces...
2.
Lee Y, Kang S, Thuy L, Son M, Park J, Ahn S, et al.
Asian J Pharm Sci
. 2025 Feb;
20(1):101006.
PMID: 39931357
Herpes simplex virus thymidine kinase (HSVtk) gene therapy is a promising strategy for glioblastoma therapy. However, delivery of plasmid DNA (pDNA) encoding HSVtk into the brain by systemic administration is...
3.
Jung O, Jung H, Thuy L, Choi M, Kim S, Jeon H, et al.
Adv Healthc Mater
. 2024 Feb;
13(14):e2303857.
PMID: 38344923
Recently, mRNA-based therapeutics, including vaccines, have gained significant attention in the field of gene therapy for treating various diseases. Among the various mRNA delivery vehicles, lipid nanoparticles (LNPs) have emerged...
4.
Kim S, Thuy L, Lee J, Choi J
Molecules
. 2023 Nov;
28(22).
PMID: 38005366
Poly(amidoamine) (PAMAM) dendrimers have attracted considerable attention in the field of gene therapy due to their flexibility in introducing different functional moieties and reduced toxicity at low generations. However, their...
5.
Jung S, Lee H, Shin H, Choi J, Kim S, Ku B
J Microbiol
. 2023 Sep;
61(8):755-764.
PMID: 37684534
Human papillomaviruses (HPVs) can increase the proliferation of infected cells during HPV-driven abnormalities, such as cervical cancer or benign warts. To date, more than 200 HPV genotypes have been identified,...
6.
Lim D, Jeong D, Shin H, Choi J, Seo J, Kim S, et al.
Proteins
. 2023 Aug;
92(1):44-51.
PMID: 37553948
The activation or inactivation of B-cell lymphoma-2 (Bcl-2) antagonist/killer (Bak) is critical for controlling mitochondrial outer membrane permeabilization-dependent apoptosis. Its pro-apoptotic activity is controlled by intermolecular interactions with the Bcl-2...
7.
Thuy L, Kim S, Dongquoc V, Kim Y, Choi J, Cho W
Int J Biol Macromol
. 2023 Aug;
249:126090.
PMID: 37541478
To prevent bacterial contamination on solid surfaces, a simple yet efficient antibacterial coating was developed in a substrate-independent manner by using the catechol-conjugated carboxymethyl chitosan (CMC-DOPA). The CMC-DOPA was firstly...
8.
Lim D, Choe S, Jin S, Lee S, Kim Y, Shin H, et al.
PLoS Biol
. 2023 Jun;
21(6):e3002156.
PMID: 37315086
Bak is a critical executor of apoptosis belonging to the Bcl-2 protein family. Bak contains a hydrophobic groove where the BH3 domain of proapoptotic Bcl-2 family members can be accommodated,...
9.
Kang N, Thuy L, Dongquoc V, Choi J
Pharmaceutics
. 2023 Mar;
15(3).
PMID: 36986864
The growing evolution of bacterial resistance to antibiotics represents a global issue that not only impacts healthcare systems but also political and economic processes. This necessitates the development of novel...
10.
Thuy L, Lee S, Dongquoc V, Choi J
Antioxidants (Basel)
. 2023 Feb;
12(2).
PMID: 36829996
Targeted drugs have been used to treat mitochondrial dysfunction-related diseases, including metabolic disorders and cancer; however, targeting and penetrating intracellular organelles remains a challenge. Dominant targeting approaches for therapeutic delivery...