Jonathan S Draper
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Explore the profile of Jonathan S Draper including associated specialties, affiliations and a list of published articles.
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22
Citations
1688
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Recent Articles
1.
Ludwig T, Andrews P, Barbaric I, Benvenisty N, Bhattacharyya A, Crook J, et al.
Stem Cell Reports
. 2023 Sep;
18(9):1744-1752.
PMID: 37703820
The laboratory culture of human stem cells seeks to capture a cellular state as an in vitro surrogate of a biological system. For the results and outputs from this research...
2.
Andrews P, Barbaric I, Benvenisty N, Draper J, Ludwig T, Merkle F, et al.
Cell Stem Cell
. 2022 Dec;
29(12):1624-1636.
PMID: 36459966
It is well established that human pluripotent stem cells (hPSCs) can acquire genetic and epigenetic changes during culture in vitro. Given the increasing use of hPSCs in research and therapy...
3.
Ly M, Rentas S, Vujovic A, Wong N, Moreira S, Xu J, et al.
Cancer Res
. 2019 Sep;
79(22):5799-5811.
PMID: 31519687
Eliminating leukemic stem cells (LSC) is a sought after therapeutic paradigm for the treatment of acute myeloid leukemia (AML). While repression of aryl hydrocarbon receptor (AHR) signaling has been shown...
4.
Belew M, Bhatia S, Keyvani Chahi A, Rentas S, Draper J, Hope K
Stem Cell Reports
. 2018 Apr;
10(4):1384-1397.
PMID: 29641991
MSI2, which is expressed predominantly in hematopoietic stem and progenitor cells (HSPCs), enforces HSPC expansion when overexpressed and is upregulated in myeloid leukemias, indicating its regulated transcription is critical to...
5.
Nadkarni R, Abed S, Cox B, Bhatia S, Lau J, Surette M, et al.
Stem Cell Reports
. 2017 Sep;
9(3):897-912.
PMID: 28867347
Intestinal organoids derived from human pluripotent stem cells (hPSCs) are valuable in vitro research models that enable simplified access to human gastrointestinal tissues. Here, we report the in vitro generation...
6.
Nadkarni R, Abed S, Draper J
Chest
. 2017 Aug;
153(4):994-1003.
PMID: 28780147
The epithelial cells lining the mammalian lung are subjected to constant interaction with the external environment, necessitating robust regeneration strategies to deal with cell loss due to natural turnover or...
7.
Nadkarni R, Abed S, Draper J
Biochem Biophys Res Commun
. 2016 Jan;
473(3):675-82.
PMID: 26721435
The lung is a complex organ comprising multiple cell types that perform a variety of vital processes, including immune defense and gas exchange. Diseases of the lung, such as chronic...
8.
Hallett R, Huang C, Motazedian A, Auf der Mauer S, Pond G, Hassell J, et al.
Oncotarget
. 2015 Mar;
6(9):7040-52.
PMID: 25749523
Chemotherapy fails to provide durable cure for the majority of cancer patients. To identify mechanisms associated with chemotherapy resistance, we identified genes differentially expressed before and after chemotherapeutic treatment of...
9.
Bhatia S, Pilquil C, Roth-Albin I, Draper J
PLoS One
. 2013 Feb;
8(2):e57276.
PMID: 23437358
Heterogeneity is a feature of stem cell populations, resulting from innate cellular hierarchies that govern differentiation capability. How heterogeneity impacts human pluripotent stem cell populations is directly relevant to their...
10.
Calder A, Roth-Albin I, Bhatia S, Pilquil C, Lee J, Bhatia M, et al.
Stem Cells Dev
. 2012 Jul;
22(2):279-95.
PMID: 22827698
The cell cycle in pluripotent stem cells is notable for the brevity of the G1 phase, permitting rapid proliferation and reducing the duration of differentiation signal sensitivity associated with the...