Jonathan Rt Lakey
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Explore the profile of Jonathan Rt Lakey including associated specialties, affiliations and a list of published articles.
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11
Citations
135
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Recent Articles
1.
Lakey J, Casazza K, Lernhardt W, Mathur E, Jenkins I
Curr Diabetes Rev
. 2024 Feb;
PMID: 38303524
Background: The global incidence of type 2 diabetes (T2D) persists at epidemic proportions. Early diagnosis and/or preventive efforts are critical to attenuate the multi-systemic clinical manifestation and consequent healthcare burden....
2.
Kojayan G, Flores A, Li S, Alexander M, Lakey J
Cell Med
. 2021 Sep;
11:2155179019876641.
PMID: 34557325
Islet transplantation has been shown to restore normoglycemia clinically. One of the current limitations to the widespread clinical use of islet transplantation is culturing and preserving more than 1 million...
3.
Lau H, Li S, Corrales N, Rodriguez S, Mohammadi M, Alexander M, et al.
Int J Mol Sci
. 2021 Aug;
22(16).
PMID: 34445075
Pre-weaned porcine islets (PPIs) represent an unlimited source for islet transplantation but are functionally immature. We previously showed that necrostatin-1 (Nec-1) immediately after islet isolation enhanced the in vitro development...
4.
Whaley D, Damyar K, Witek R, Mendoza A, Alexander M, Lakey J
Cell Transplant
. 2021 Mar;
30:963689721999617.
PMID: 33757335
The origins of low-temperature tissue storage research date back to the late 1800s. Over half a century later, osmotic stress was revealed to be a main contributor to cell death...
5.
Corrales N, Park S, Lau H, Xu I, Luong C, Rodriguez S, et al.
Cell Transplant
. 2020 Dec;
29:963689720977835.
PMID: 33267618
For the advancement of porcine xenotransplantation for clinical use in type 1 diabetes mellitus, the concerns of a sustainable and safe digestion enzyme blend must be overcome. Incorporating good manufacturing...
6.
Mohammadi M, Dehkordi-Vakil F, Ricks-Oddie J, Mansfield R, Kashmiri H, Daniels M, et al.
Cell Transplant
. 2020 Oct;
29:963689720952343.
PMID: 33023311
Transplantation of pancreatic islets within a biomaterial device is currently under investigation in clinical trials for the treatment of patients with type 1 diabetes (T1D). Patients' preferences on such implants...
7.
Kojayan G, Whaley D, Alexander M, Rodriguez S, Lee S, Lakey J
Cryobiology
. 2019 Apr;
88:23-28.
PMID: 30991035
Islet transplantation has been shown to restore normoglycemia in animal models and for type 1 diabetic patients in clinical trials. One method of storing islets intended for transplantation is via...
8.
Sathialingam M, Saidian M, Zhang S, Flores A, Alexander M, Lakey J
J Diet Suppl
. 2018 Jun;
16(4):454-462.
PMID: 29958040
Cycloferin is an extract of the chemicals from the species, which grows only in small areas in the southwest and southeast of South Africa and has been consumed traditionally as...
9.
Gurlin R, Keating M, Li S, Lakey J, de Feraudy S, Shergill B, et al.
J Tissue Eng
. 2017 Feb;
8:2041731417691645.
PMID: 28228933
Success of cell therapy in avascular sites will depend on providing sufficient blood supply to transplanted tissues. A popular strategy of providing blood supply is to embed cells within a...
10.
Krishnan R, Buder B, Alexander M, Foster 3rd C, Lakey J
Transplantation
. 2015 Mar;
99(4):710-6.
PMID: 25793438
Background: Porcine islet xenotransplantation has been demonstrated in many animal studies to cure experimentally induced diabetes. However, several issues currently impede the translation of porcine islet xenotransplantation to sustained insulin...