Jonathan R Weinstein
Overview
Explore the profile of Jonathan R Weinstein including associated specialties, affiliations and a list of published articles.
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30
Citations
526
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Recent Articles
1.
Adler-Wachter M, Tsai J, Schweitzer B, McDonough A, Snyder J, Barker-Haliski M, et al.
bioRxiv
. 2024 Dec;
PMID: 39651141
Significance Statement: Medium chain triglycerides (MCTs) are commonly used as an excipient in pharmacological studies involving laboratory animals. Our work provides much needed safety information regarding adverse effects of repeated...
2.
Weinstein J, Jayadev S, Liddelow S, Eggen B
Glia
. 2024 Nov;
73(3):448-450.
PMID: 39587765
No abstract available.
3.
McDonough A, Weinstein J
Glia
. 2024 Oct;
73(3):495-518.
PMID: 39463002
Vascular injury and pathologies underlie common diseases including ischemic stroke and cerebral small vessel disease (CSVD). Prior work has identified a key role for glial cells, including microglia, in the...
4.
Lee R, Chen Y, Nguyen H, Singh L, Dietrich C, Pyles B, et al.
Transl Stroke Res
. 2023 Apr;
15(3):518-532.
PMID: 37088858
Senicapoc, a small molecule inhibitor of the calcium-activated potassium channel KCa3.1, was safe and well-tolerated in clinical trials for sickle cell anemia. We previously reported proof-of-concept data suggesting that both...
5.
Hamner M, McDonough A, Gong D, Todd L, Rojas G, Hodecker S, et al.
Glia
. 2021 Dec;
70(4):661-674.
PMID: 34939240
Ischemic preconditioning (IPC) is a phenomenon whereby a brief, non-injurious ischemic exposure enhances tolerance to a subsequent ischemic challenge. The mechanism of IPC has mainly been studied in rodent stroke...
6.
Prater K, Aloi M, Pathan J, Winston C, Chernoff R, Davidson S, et al.
J Neurosci
. 2021 Aug;
41(38):7942-7953.
PMID: 34380760
Microglia maintain brain health and play important roles in disease and injury. Despite the known ability of microglia to proliferate, the precise nature of the population or populations capable of...
7.
McDonough A, Noor S, Lee R, Dodge 3rd R, Strosnider J, Shen J, et al.
Glia
. 2019 Aug;
68(1):76-94.
PMID: 31420975
Ischemic preconditioning (IPC) is an experimental phenomenon in which a subthreshold ischemic insult applied to the brain reduces damage caused by a subsequent more severe ischemic episode. Identifying key molecular...
8.
McDonough A, Weinstein J
Glia
. 2019 Aug;
68(3):455-471.
PMID: 31386233
Ischemic preconditioning (IPC) is an experimental phenomenon in which a brief ischemic stimulus confers protection against a subsequent prolonged ischemic event. Initially thought to be due to mechanistic changes in...
9.
McDonough A, Weinstein J
Neurotherapeutics
. 2017 Nov;
15(2):511-524.
PMID: 29110213
Ischemic preconditioning (IPC) is a robust neuroprotective phenomenon in which a brief period of cerebral ischemia confers transient tolerance to subsequent ischemic challenge. Research on IPC has implicated cellular, molecular,...
10.
McDonough A, Lee R, Noor S, Lee C, Le T, Iorga M, et al.
J Neurosci
. 2017 Jul;
37(34):8292-8308.
PMID: 28747383
Innate immune signaling is important in the pathophysiology of ischemia/reperfusion (stroke)-induced injury and recovery. Several lines of evidence support a central role for microglia in these processes. Recent work has...