Jonathan McCone
Overview
Explore the profile of Jonathan McCone including associated specialties, affiliations and a list of published articles.
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10
Citations
921
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0
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Recent Articles
1.
Vierling J, Davis M, Flamm S, Gordon S, Lawitz E, Yoshida E, et al.
J Hepatol
. 2013 Dec;
60(4):748-56.
PMID: 24362076
Background & Aims: Boceprevir with peginterferon/ribavirin (BOC/PR) leads to significantly higher sustained virological response (SVR) rates in patients with chronic hepatitis C and partial response or relapse after prior treatment...
2.
Ogert R, Howe J, Vierling J, Kwo P, Lawitz E, McCone J, et al.
Antivir Ther
. 2013 Feb;
18(3):387-97.
PMID: 23406826
Background: Resistance to direct-acting antivirals represents a new challenge in the treatment of chronic hepatitis C. Methods: SPRINT-1 was a randomized study of treatment-naive patients with genotype (G) 1 hepatitis...
3.
Thompson A, Clark P, Singh A, Ge D, Fellay J, Zhu M, et al.
J Hepatol
. 2011 Jun;
56(2):313-9.
PMID: 21703177
Background & Aims: Interferon-alfa (IFN)-related cytopenias are common and may be dose-limiting. We performed a genome wide association study on a well-characterized genotype 1 HCV cohort to identify genetic determinants...
4.
Melia M, Muir A, McCone J, Shiffman M, King J, Herrine S, et al.
Hepatology
. 2011 Apr;
54(1):70-8.
PMID: 21488082
Unlabelled: Black Americans are disproportionally infected with hepatitis C virus (HCV) and are less likely than whites to respond to treatment with peginterferon (PEG-IFN) plus ribavirin (RBV). The impact of...
5.
Sulkowski M, Shiffman M, Afdhal N, Reddy K, McCone J, Lee W, et al.
Gastroenterology
. 2010 Aug;
139(5):1602-11, 1611.e1.
PMID: 20723545
Background & Aims: Hepatitis C virus (HCV) treatment is frequently complicated by anemia from ribavirin (RBV)-related hemolysis and peginterferon-alfa (PEG-IFN)-related bone marrow suppression. We investigated the relationships among treatment outcomes,...
6.
Kwo P, Lawitz E, McCone J, Schiff E, Vierling J, Pound D, et al.
Lancet
. 2010 Aug;
376(9742):705-16.
PMID: 20692693
Background: Peginterferon plus ribavirin achieves sustained virological response (SVR) in fewer than half of patients with genotype 1 chronic hepatitis C virus infection treated for 48 weeks. We tested the...
7.
Thompson A, Muir A, Sulkowski M, Ge D, Fellay J, Shianna K, et al.
Gastroenterology
. 2010 Apr;
139(1):120-9.e18.
PMID: 20399780
Background & Aims: We recently identified a polymorphism upstream of interleukin (IL)-28B to be associated with a 2-fold difference in sustained virologic response (SVR) rates to pegylated interferon-alfa and ribavirin...
8.
McHutchison J, Lawitz E, Shiffman M, Muir A, Galler G, McCone J, et al.
N Engl J Med
. 2009 Jul;
361(6):580-93.
PMID: 19625712
Background: Treatment guidelines recommend the use of peginterferon alfa-2b or peginterferon alfa-2a in combination with ribavirin for chronic hepatitis C virus (HCV) infection. However, these regimens have not been adequately...
9.
Jacobson I, Brown Jr R, McCone J, Black M, Albert C, Dragutsky M, et al.
Hepatology
. 2007 Sep;
46(4):982-90.
PMID: 17894323
Unlabelled: WIN-R (Weight-based dosing of pegINterferon alfa-2b and Ribavirin) was a multicenter, randomized, open-label, investigator-initiated trial involving 236 community and academic sites in the United States, comparing response to pegylated...
10.
Cotler S, Craft T, Ferris M, Morrisey M, McCone J, Reddy K, et al.
J Interferon Cytokine Res
. 2002 Jun;
22(5):549-54.
PMID: 12060493
Hepatitis C virus (HCV) infection is resistant to interferon-alpha (IFN-alpha) in some patients. The mechanism of this resistance is unknown. Interleukin-1 receptor antagonist (IL-1Ra) is induced by IFN-alpha and is...