Jonathan M Galazka
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Explore the profile of Jonathan M Galazka including associated specialties, affiliations and a list of published articles.
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41
Citations
972
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Recent Articles
1.
Casaletto J, Scott R, Myrick M, Mackintosh G, Chok H, Saravia-Butler A, et al.
Sci Rep
. 2025 Jan;
15(1):2363.
PMID: 39824847
Spaceflight has several detrimental effects on human and rodent health. For example, liver dysfunction is a common phenotype observed in space-flown rodents, and this dysfunction is partially reflected in transcriptomic...
2.
Siew K, Nestler K, Nelson C, DAmbrosio V, Zhong C, Li Z, et al.
Nat Commun
. 2024 Jun;
15(1):4923.
PMID: 38862484
Missions into Deep Space are planned this decade. Yet the health consequences of exposure to microgravity and galactic cosmic radiation (GCR) over years-long missions on indispensable visceral organs such as...
3.
Masarapu Y, Cekanaviciute E, Andrusivova Z, Westholm J, Bjorklund A, Fallegger R, et al.
Nat Commun
. 2024 Jun;
15(1):4778.
PMID: 38862479
Impairment of the central nervous system (CNS) poses a significant health risk for astronauts during long-duration space missions. In this study, we employed an innovative approach by integrating single-cell multiomics...
4.
Soundararajan M, Paddock M, Dougherty M, Jones H, Hogan J, Donovan F, et al.
NPJ Microgravity
. 2023 Sep;
9(1):78.
PMID: 37717090
Space-based biomanufacturing has the potential to improve the sustainability of deep space exploration. To advance biomanufacturing, bioprocessing systems need to be developed for space applications. Here, commercial technologies were assessed...
5.
Flores P, McBride S, Galazka J, Varanasi K, Zea L
NPJ Microgravity
. 2023 Aug;
9(1):66.
PMID: 37587131
The undesirable, yet inevitable, presence of bacterial biofilms in spacecraft poses a risk to the proper functioning of systems and to astronauts' health. To mitigate the risks that arise from...
6.
Overbey E, Das S, Cope H, Madrigal P, Andrusivova Z, Frapard S, et al.
Cell Rep Methods
. 2022 Dec;
2(11):100325.
PMID: 36452864
Single-cell RNA sequencing (scRNA-seq) and spatially resolved transcriptomics (SRT) have experienced rapid development in recent years. The findings of spaceflight-based scRNA-seq and SRT investigations are likely to improve our understanding...
7.
Nwanaji-Enwerem J, Boileau P, Galazka J, Cardenas A
Environ Mol Mutagen
. 2022 Apr;
63(4):184-189.
PMID: 35470505
Ionizing radiation is a well-appreciated health risk, precipitant of DNA damage, and contributor to DNA methylation variability. Nevertheless, relationships of ionizing radiation with DNA methylation-based markers of biological age (i.e....
8.
Bowen C, Sargent C, Wang A, Zhu Y, Chang X, Li J, et al.
Nat Commun
. 2021 Aug;
12(1):5182.
PMID: 34462443
Manmade high-performance polymers are typically non-biodegradable and derived from petroleum feedstock through energy intensive processes involving toxic solvents and byproducts. While engineered microbes have been used for renewable production of...
9.
Paul A, Overbey E, da Silveira W, Szewczyk N, Nishiyama N, Pecaut M, et al.
Sci Rep
. 2021 Jun;
11(1):11452.
PMID: 34075076
Using a ground-based model to simulate spaceflight [21-days of single-housed, hindlimb unloading (HLU) combined with continuous low-dose gamma irradiation (LDR, total dose of 0.04 Gy)], an in-depth survey of the...
10.
Nguyen H, Tran D, Galazka J, Costes S, Beheshti A, Petereit J, et al.
Nucleic Acids Res
. 2021 May;
49(W1):W114-W124.
PMID: 34037798
In molecular biology and genetics, there is a large gap between the ease of data collection and our ability to extract knowledge from these data. Contributing to this gap is...