Jonathan M Brotchie
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Explore the profile of Jonathan M Brotchie including associated specialties, affiliations and a list of published articles.
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126
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3014
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Recent Articles
1.
Hofman K, Chen J, Sil T, Pellegrini F, Haufe S, Pozzi N, et al.
Brain
. 2025 Feb;
PMID: 39965098
Elevated beta (β; 13-30 Hz) synchronization within the subthalamic nucleus (STN) characterizes bradykinesia in Parkinson's disease (PD). β oscillations may serve as biomarkers for off-period motor symptoms and control signals...
2.
McFleder R, Musacchio T, Keller J, Knorr S, Petschner T, Chen J, et al.
Brain Behav Immun
. 2024 Oct;
123:851-862.
PMID: 39481497
Immune dysregulation in the brain and periphery is thought to contribute to the detrimental neurodegeneration that occurs in Parkinson's disease (PD). Identifying mechanisms to reverse this dysregulation is key to...
3.
Johnston T, Lacoste A, Ravenscroft P, Su J, Tamadon S, Seifi M, et al.
Neuropharmacology
. 2024 Feb;
248:109880.
PMID: 38412888
Repurposing regulatory agency-approved molecules, with proven safety in humans, is an attractive option for developing new treatments for disease. We identified and assessed the efficacy of 3 drugs predicted by...
4.
McFleder R, Makhotkina A, Groh J, Keber U, Imdahl F, Pena Mosca J, et al.
Nat Commun
. 2023 Nov;
14(1):7529.
PMID: 37981650
Inflammation in the brain and gut is a critical component of several neurological diseases, such as Parkinson's disease (PD). One trigger of the immune system in PD is aggregation of...
5.
Grotemeyer A, Fischer J, Koprich J, Brotchie J, Blum R, Volkmann J, et al.
J Neuroinflammation
. 2023 Mar;
20(1):79.
PMID: 36945016
Neuroinflammation has been suggested as a pathogenetic mechanism contributing to Parkinson's disease (PD). However, anti-inflammatory treatment strategies have not yet been established as a therapeutic option for PD patients. We...
6.
Badr M, McFleder R, Wu J, Knorr S, Koprich J, Hunig T, et al.
J Neuroinflammation
. 2022 Dec;
19(1):319.
PMID: 36587195
Background: Regulatory CD4CD25FoxP3 T cells (Treg) are a subgroup of T lymphocytes involved in maintaining immune balance. Disturbance of Treg number and impaired suppressive function of Treg correlate with Parkinson's...
7.
Wuest M, Bailey J, Dufour J, Glubrecht D, Omana V, Johnston T, et al.
EJNMMI Res
. 2022 Jul;
12(1):46.
PMID: 35907096
Background: Tropomyosin receptor kinases (TrkA, TrkB, TrkC) are a family of tyrosine kinases primarily expressed in neuronal cells of the brain. Identification of oncogenic alterations in Trk expression as a...
8.
Musacchio T, Yin J, Kremer F, Koprich J, Brotchie J, Volkmann J, et al.
Behav Brain Res
. 2022 Jun;
432:113968.
PMID: 35738338
Degeneration of the nigrostriatal tract is a neuropathological hallmark of Parkinson's disease (PD). A differential intraneuronal vulnerability of dopaminergic neurons within the substantia nigra (SN) has been suggested, starting as...
9.
Matschke L, Komadowski M, Stohr A, Lee B, Henrich M, Griesbach M, et al.
Sci Rep
. 2022 Feb;
12(1):3180.
PMID: 35210472
Parkinson's disease (PD) is clinically defined by the presence of the cardinal motor symptoms, which are associated with a loss of dopaminergic nigrostriatal neurons in the substantia nigra pars compacta...
10.
Karikari A, McFleder R, Ribechini E, Blum R, Bruttel V, Knorr S, et al.
Brain Behav Immun
. 2022 Jan;
101:194-210.
PMID: 35032575
Background: Antigen-specific neuroinflammation and neurodegeneration are characteristic for neuroimmunological diseases. In Parkinson's disease (PD) pathogenesis, α-synuclein is a known culprit. Evidence for α-synuclein-specific T cell responses was recently obtained in...