Jonathan J Hirst
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Explore the profile of Jonathan J Hirst including associated specialties, affiliations and a list of published articles.
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65
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644
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Recent Articles
1.
Pavy C, Shaw J, Palliser H, Moloney R, Hirst J
J Dev Orig Health Dis
. 2025 Jan;
16():e2.
PMID: 39773606
Preterm birth exposes the neonate to hypoxic-ischaemic and excitotoxic insults that impair neurodevelopment and are magnified by the premature loss of placentally supplied, inhibitory neurosteroids. The cerebellum is a neuronally...
2.
Hirst J, Palliser H, Pavy C, Shaw J, Moloney R
Front Neuroendocrinol
. 2024 Dec;
76:101169.
PMID: 39622477
The levels of the key neurosteroid of pregnancy, allopregnanolone, are very high in the fetal and maternal brain compared to after birth. These levels are maintained by the placenta which...
3.
Fisher J, Grace T, Castles N, Jones E, Delforce S, Peters A, et al.
JMIR Res Protoc
. 2024 Nov;
13:e63562.
PMID: 39546349
Background: Research in the developmental origins of health and disease provides compelling evidence that adverse events during the first 1000 days of life from conception can impact life course health....
4.
Pavy C, Shaw J, Dyson R, Palliser H, Moloney R, Sixtus R, et al.
Dev Psychobiol
. 2024 Oct;
66(7):e22554.
PMID: 39378309
The postnatal environment is challenging for the preterm neonate with exposure to hypoxic and excitotoxic events, amplified by premature loss of placentally derived neurosteroids. Between preterm birth and term equivalent...
5.
Moloney R, Palliser H, Pavy C, Shaw J, Hirst J
Brain Behav
. 2024 Sep;
14(9):e70009.
PMID: 39236116
Background: Preterm birth is associated with brain injury and long-term behavioral abnormalities, for which there are limited prevention options. When born preterm, infants prematurely lose placental neurosteroid (allopregnanolone) support. This...
6.
Grace T, Fisher J, Wang C, Valkenborghs S, Smith R, Hirst J, et al.
BMJ Open
. 2023 Jul;
13(7):e072205.
PMID: 37451724
Introduction: Multiple cohort studies have been established to investigate the impact of early life factors on development and health outcomes. In Australia the majority of these studies were established more...
7.
Crombie G, Palliser H, Shaw J, Hanley B, Moloney R, Hirst J
Dev Neurosci
. 2023 Apr;
45(5):290-308.
PMID: 37004512
Disruptions to neurodevelopment are known to be linked to behavioral disorders in childhood and into adulthood. The fetal brain is extremely vulnerable to stimuli that alter inhibitory GABAergic pathways and...
8.
Ajgaonkar S, Hirst J, Norris M, Zakar T
PLoS One
. 2023 Mar;
18(3):e0280645.
PMID: 36897880
The decidua undergoes proinflammatory activation in late pregnancy, promoting labor. Bromodomain and Extra-Terminal (BET) family proteins interact with acetylated histones and may control gene expression in inflammation. Here, we assessed...
9.
Miller S, Bennet L, Sutherland A, Pham Y, McDonald C, Castillo-Melendez M, et al.
Ann Neurol
. 2022 Sep;
92(6):1066-1079.
PMID: 36054160
Objective: Seizures are more common in the neonatal period than at any other stage of life. Phenobarbital is the first-line treatment for neonatal seizures and is at best effective in...
10.
Shaw J, Dyson R, Palliser H, Sixtus R, Barnes H, Pavy C, et al.
Front Physiol
. 2022 May;
13:871265.
PMID: 35514343
Preterm birth can lead to brain injury and currently there are no targeted therapies to promote postnatal brain development and protect these vulnerable neonates. We have previously shown that the...