Jonathan J Abramson
Overview
Explore the profile of Jonathan J Abramson including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
240
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0
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Recent Articles
1.
Klipp R, Li N, Wang Q, Word T, Sibrian-Vazquez M, Strongin R, et al.
Heart Rhythm
. 2017 Dec;
15(4):578-586.
PMID: 29248564
Background: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an arrhythmogenic disorder caused by mutations in the cardiac ryanodine receptor RyR2 that increase diastolic calcium cation (Ca) leak from the sarcoplasmic reticulum...
2.
Grzelczak M, Danks S, Klipp R, Belic D, Zaulet A, Kunstmann-Olsen C, et al.
ACS Nano
. 2017 Nov;
11(12):12492-12499.
PMID: 29161496
Carborane-capped gold nanoparticles (Au/carborane NPs, 2-3 nm) can act as artificial ion transporters across biological membranes. The particles themselves are large hydrophobic anions that have the ability to disperse in...
3.
Li N, Wang Q, Sibrian-Vazquez M, Klipp R, Reynolds J, Word T, et al.
Int J Cardiol
. 2016 Nov;
227():668-673.
PMID: 27838126
Rationale: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a potentially lethal arrhythmic disorder caused by mutations in the type-2 ryanodine receptor (RyR2). Mutant RyR2 cause abnormal Ca leak from the sarcoplasmic...
4.
Kim J, Nemec J, Papp R, Strongin R, Abramson J, Salama G
Am J Physiol Heart Circ Physiol
. 2013 Jan;
304(6):H848-60.
PMID: 23316064
Bradycardia prolongs action potential (AP) durations (APD adaptation), enhances dispersion of repolarization (DOR), and promotes tachyarrhythmias. Yet, the mechanisms responsible for enhanced DOR and tachyarrhythmias remain largely unexplored. Ca(2+) transients...
5.
Parikh A, Mantravadi R, Kozhevnikov D, Roche M, Ye Y, Owen L, et al.
Heart Rhythm
. 2012 Jan;
9(6):953-60.
PMID: 22245792
Background: Ranolazine (Ran) is known to inhibit multiple targets, including the late Na(+)current, the rapid delayed rectifying K(+)current, the L-type Ca(2+)current, and fatty acid metabolism. Functionally, Ran suppresses early afterdepolarization...
6.
Ye Y, Yaeger D, Owen L, Escobedo J, Wang J, Singer J, et al.
Mol Pharmacol
. 2011 Oct;
81(1):53-62.
PMID: 21989257
New drugs with enhanced electron donor properties that target the ryanodine receptor from skeletal muscle sarcoplasmic reticulum (RyR1) are shown to be potent inhibitors of single-channel activity. In this article,...
7.
Smejtek P, Satterfield L, Word R, Abramson J
Biochim Biophys Acta
. 2010 May;
1798(9):1689-97.
PMID: 20471362
Establishing the origin of electrophoretic mobility of sarcoplasmic reticulum (SR) vesicles is the primary goal of this work. It was found that the electrophoretic mobility originates from ionizable amino acids...
8.
Jurynec M, Xia R, Mackrill J, Gunther D, Crawford T, Flanigan K, et al.
Proc Natl Acad Sci U S A
. 2008 Aug;
105(34):12485-90.
PMID: 18713863
Mutations affecting the seemingly unrelated gene products, SepN1, a selenoprotein of unknown function, and RyR1, the major component of the ryanodine receptor intracellular calcium release channel, result in an overlapping...
9.
Marinov B, Olojo R, Xia R, Abramson J
Antioxid Redox Signal
. 2007 May;
9(5):609-21.
PMID: 17465884
The Ca(2+) release channel (CRC) from sarcoplasmic reticulum (SR) is rich in thiol groups, and their oxidation/- reduction by thiol reagents activates/inhibits the CRC. Most channel regulators are not thiol...
10.
Marinov B, Bend E, Abramson J
Photochem Photobiol
. 2006 Oct;
82(6):1566-71.
PMID: 17017846
The calcium release channel (CRC) of the skeletal sarcoplasmic reticulum is rich in thiol groups and is strongly regulated by covalent modification of these thiols. Oxidizing reagents activate the release...