Jonathan Cowman
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Explore the profile of Jonathan Cowman including associated specialties, affiliations and a list of published articles.
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8
Citations
63
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Recent Articles
1.
Cowman J, Richter L, Walsh R, Keegan N, Tinago W, Ricco A, et al.
Platelets
. 2018 Sep;
30(6):737-742.
PMID: 30252557
Despite a fivefold increased risk of thromboembolism in patients with cancer, the mechanism of arterial thromboembolism is poorly understood. To address this, we investigated platelet function in cancer patients and...
2.
Kennedy C, Wong L, Sexton D, Cowman J, Oglesby I, Kenny M, et al.
Clin Kidney J
. 2018 Aug;
11(4):574-580.
PMID: 30087773
Background: Uraemic platelet dysfunction is not completely understood, in part due to non-physiological platelet function assays. We have developed a physiological flow-based assay that quantifies platelet function in microlitre volumes...
3.
Cowman J, Mullers S, Dunne E, Ralph A, Ricco A, Malone F, et al.
Sci Rep
. 2017 Jul;
7(1):6354.
PMID: 28743915
Platelet function in pregnancy is poorly understood. Previous studies of platelet function in pregnancy have used non-physiological assays of platelet function with conflicting results. This study using a physiological assay...
4.
Ralph A, Somers M, Cowman J, Voisin B, Hogan E, Dunne H, et al.
Cardiovasc Eng Technol
. 2016 Oct;
7(4):389-405.
PMID: 27743349
The imaging of shear-mediated dynamic platelet behavior interacting with surface-immobilized von Willebrand factor (vWF) has tremendous potential in characterizing changes in platelet function for clinical diagnostics purposes. However, the imaging...
5.
Mullers S, Burke N, Flood K, Cowman J, OConnor H, Cotter B, et al.
Am J Perinatol
. 2016 Feb;
33(8):791-9.
PMID: 26906182
Objective A limited number of platelet function studies in intrauterine growth restriction (IUGR) have yielded conflicting results. We sought to evaluate platelet reactivity in IUGR using a novel platelet aggregation...
6.
Cowman J, Dunne E, Oglesby I, Byrne B, Ralph A, Voisin B, et al.
Sci Rep
. 2015 Jul;
5:12235.
PMID: 26179119
Age is a risk factor for cardiovascular disease (CVD), however the effect of age on platelet function remains unclear. Ideally, platelet function should be assayed under flow and shear conditions...
7.
Fitzgibbon S, Cowman J, Ricco A, Kenny D, Shaqfeh E
Soft Matter
. 2014 Nov;
11(2):355-67.
PMID: 25382632
While critically important, the platelet function at the high shear rates typical of the microcirculation is relatively poorly understood. Using a large scale Stokes flow simulation, Zhao et al. recently...
8.
Lucitt M, OBrien S, Cowman J, Meade G, Basabe-Desmonts L, Somers M, et al.
Anal Bioanal Chem
. 2013 Mar;
405(14):4823-34.
PMID: 23535745
We report the development and demonstration of an assay that distinguishes the pharmacological effects of two widely used antiplatelet therapies, aspirin (COX-1 inhibitor) and clopidogrel (P2Y12 inhibitor). Whole blood is...