Jonathan C Niclis
Overview
Explore the profile of Jonathan C Niclis including associated specialties, affiliations and a list of published articles.
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14
Citations
346
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Recent Articles
1.
Gantner C, Hunt C, Niclis J, Penna V, McDougall S, Thompson L, et al.
Stem Cell Reports
. 2021 Apr;
16(5):1262-1275.
PMID: 33836146
Despite heterogeneity across the six layers of the mammalian cortex, all excitatory neurons are generated from a single founder population of neuroepithelial stem cells. However, how these progenitors alter their...
2.
Gantner C, de Luzy I, Kauhausen J, Moriarty N, Niclis J, Bye C, et al.
Cell Stem Cell
. 2020 Feb;
26(4):511-526.e5.
PMID: 32059808
Dopaminergic neurons (DAns), generated from human pluripotent stem cells (hPSCs), are capable of functionally integrating following transplantation and have recently advanced to clinical trials for Parkinson's disease (PD). However, pre-clinical...
3.
de Luzy I, Niclis J, Gantner C, Kauhausen J, Hunt C, Ermine C, et al.
J Neurosci
. 2019 Oct;
39(48):9521-9531.
PMID: 31641054
Human pluripotent stem cells (hPSCs) are a promising resource for the replacement of degenerated ventral midbrain dopaminergic (vmDA) neurons in Parkinson's disease. Despite recent advances in protocols for the generation...
4.
Alsanie W, Niclis J, Hunt C, de Luzy I, Penna V, Bye C, et al.
Sci Rep
. 2017 Nov;
7(1):16001.
PMID: 29167563
Pluripotent stem cells (PSCs) are a valuable tool for interrogating development, disease modelling, drug discovery and transplantation. Despite the burgeoned capability to fate restrict human PSCs to specific neural lineages,...
5.
Niclis J, Gantner C, Hunt C, Kauhausen J, Durnall J, Haynes J, et al.
Stem Cell Reports
. 2017 Sep;
9(3):868-882.
PMID: 28867345
Development of safe and effective stem cell-based therapies for brain repair requires an in-depth understanding of the in vivo properties of neural grafts generated from human stem cells. Replacing dopamine...
6.
Somaa F, Wang T, Niclis J, Bruggeman K, Kauhausen J, Guo H, et al.
Cell Rep
. 2017 Aug;
20(8):1964-1977.
PMID: 28834757
Stem cell transplants offer significant hope for brain repair following ischemic damage. Pre-clinical work suggests that therapeutic mechanisms may be multi-faceted, incorporating bone-fide circuit reconstruction by transplanted neurons, but also...
7.
Niclis J, Gantner C, Alsanie W, McDougall S, Bye C, Elefanty A, et al.
Stem Cells Transl Med
. 2017 Mar;
6(3):937-948.
PMID: 28297587
Recent studies have shown evidence for the functional integration of human pluripotent stem cell (hPSC)-derived ventral midbrain dopamine (vmDA) neurons in animal models of Parkinson's disease. Although these cells present...
8.
Niclis J, Turner C, Durnall J, McDougal S, Kauhausen J, Leaw B, et al.
Stem Cells Transl Med
. 2017 Feb;
6(6):1547-1556.
PMID: 28198124
The capacity for induced pluripotent stem (iPS) cells to be differentiated into a wide range of neural cell types makes them an attractive donor source for autologous neural transplantation therapies...
9.
Kao T, Labonne T, Niclis J, Chaurasia R, Lokmic Z, Qian E, et al.
Stem Cell Reports
. 2016 Sep;
7(3):518-526.
PMID: 27594589
The ability to reliably express fluorescent reporters or other genes of interest is important for using human pluripotent stem cells (hPSCs) as a platform for investigating cell fates and gene...
10.
Fernando C, Kele J, Bye C, Niclis J, Alsanie W, Blakely B, et al.
Stem Cells Dev
. 2014 May;
23(17):1991-2003.
PMID: 24803261
During development of the central nervous system, trophic, together with genetic, cues dictate the balance between cellular proliferation and differentiation. Subsequent to the birth of new neurons, additional intrinsic and...