Jonathan A R Worrall
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Explore the profile of Jonathan A R Worrall including associated specialties, affiliations and a list of published articles.
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68
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917
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Recent Articles
1.
Lucic M, Allport T, Clarke T, Williams L, Wilson M, Chaplin A, et al.
Protein Sci
. 2024 Jun;
33(7):e5073.
PMID: 38864770
A common evolutionary mechanism in biology to drive function is protein oligomerization. In prokaryotes, the symmetrical assembly of repeating protein units to form homomers is widespread, yet consideration in vitro...
2.
Pullin J, Wilson M, Clemancey M, Blondin G, Bradley J, Moore G, et al.
Angew Chem Weinheim Bergstr Ger
. 2024 Mar;
133(15):8442-8450.
PMID: 38529354
Both O and HO can oxidize iron at the ferroxidase center (FC) of bacterioferritin (EcBfr) but mechanistic details of the two reactions need clarification. UV/Vis, EPR, and Mössbauer spectroscopies have...
3.
Bolton R, Machelett M, Stubbs J, Axford D, Caramello N, Catapano L, et al.
Proc Natl Acad Sci U S A
. 2024 Mar;
121(12):e2308478121.
PMID: 38489389
The marine cyanobacterium is a main contributor to global photosynthesis, whilst being limited by iron availability. Cyanobacterial genomes generally encode two different types of FutA iron-binding proteins: periplasmic FutA2 ABC...
4.
Thompson A, Sanchez-Weatherby J, Williams L, Mikolajek H, Sandy J, Worrall J, et al.
Acta Crystallogr D Struct Biol
. 2024 Mar;
80(Pt 4):279-288.
PMID: 38488731
A considerable bottleneck in serial crystallography at XFEL and synchrotron sources is the efficient production of large quantities of homogenous, well diffracting microcrystals. Efficient high-throughput screening of batch-grown microcrystals and...
5.
Lucic M, Wilson M, Pullin J, Hough M, Svistunenko D, Worrall J
Chem Sci
. 2023 Nov;
14(44):12518-12534.
PMID: 38020392
In heme enzymes, such as members of the dye-decolorising peroxidase (DyP) family, the formation of the highly oxidising catalytic Fe(iv)-oxo intermediates following reaction with hydrogen peroxide can lead to free...
6.
Hough M, Prischi F, Worrall J
Front Mol Biosci
. 2023 Feb;
10:1113762.
PMID: 36756363
The interaction between macromolecular proteins and small molecule ligands is an essential component of cellular function. Such ligands may include enzyme substrates, molecules involved in cellular signalling or pharmaceutical drugs....
7.
Lucic M, Wilson M, Tosha T, Sugimoto H, Shilova A, Axford D, et al.
ACS Catal
. 2022 Nov;
12(21):13349-13359.
PMID: 36366763
Controlling the reactivity of high-valent Fe(IV)-O catalytic intermediates, Compounds I and II, generated in heme enzymes upon reaction with dioxygen or hydrogen peroxide, is important for function. It has been...
8.
Worrall J, Hough M
Curr Opin Struct Biol
. 2022 Oct;
77:102486.
PMID: 36274419
Enzymes with iron-containing active sites play crucial roles in catalysing a myriad of oxidative reactions essential to aerobic life. Defining the three-dimensional structures of iron enzymes in resting, oxy-bound intermediate...
9.
Moreno-Chicano T, Carey L, Axford D, Beale J, Doak R, Duyvesteyn H, et al.
IUCrJ
. 2022 Sep;
9(Pt 5):610-624.
PMID: 36071813
Room-temperature macromolecular crystallography allows protein structures to be determined under close-to-physiological conditions, permits dynamic freedom in protein motions and enables time-resolved studies. In the case of metalloenzymes that are highly...
10.
Lucic M, Wilson M, Svistunenko D, Owen R, Hough M, Worrall J
J Biol Inorg Chem
. 2021 Sep;
26(7):743-761.
PMID: 34477969
Structure determination of proteins and enzymes by X-ray crystallography remains the most widely used approach to complement functional and mechanistic studies. Capturing the structures of intact redox states in metalloenzymes...