Jona Merx
Overview
Explore the profile of Jona Merx including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
67
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0
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Recent Articles
1.
Goode E, Orozco-Moreno M, Hodgson K, Nabilah A, Murali M, Peng Z, et al.
Cancers (Basel)
. 2024 Sep;
16(17).
PMID: 39272811
Prostate cancer is a lethal solid malignancy and a leading cause of cancer-related deaths in males worldwide. Treatments, including radical prostatectomy, radiotherapy, and hormone therapy, are available and have improved...
2.
Peters T, Engelke U, de Boer S, Reintjes J, Roullet J, Broekman S, et al.
J Inherit Metab Dis
. 2023 Jul;
47(3):417-430.
PMID: 37455357
Succinic semialdehyde dehydrogenase deficiency (SSADHD) is a rare neurometabolic disorder caused by disruption of the gamma-aminobutyric acid (GABA) pathway. A more detailed understanding of its pathophysiology, beyond the accumulation of...
3.
van Outersterp R, Kooijman P, Merx J, Engelke U, Omidikia N, Tonneijck M, et al.
Anal Chem
. 2023 Jun;
95(26):9787-9796.
PMID: 37341384
Distinguishing isomeric saccharides poses a major challenge for analytical workflows based on (liquid chromatography) mass spectrometry (LC-MS). In recent years, many studies have proposed infrared ion spectroscopy as a possible...
4.
Merx J, Hintzen J, Proietti G, Elferink H, Wang Y, Porzberg M, et al.
Sci Rep
. 2022 Nov;
12(1):19251.
PMID: 36357422
Posttranslational modifications (PTMs) on histone tails regulate eukaryotic gene expression by impacting the chromatin structure and by modulating interactions with other cellular proteins. One such PTM has been identified as...
5.
Initial Steps towards Spatiotemporal Signaling through Biomaterials Using Click-to-Release Chemistry
Gansevoort M, Merx J, Versteeg E, Vuckovic I, Boltje T, van Kuppevelt T, et al.
Pharmaceutics
. 2022 Oct;
14(10).
PMID: 36297427
The process of wound healing is a tightly controlled cascade of events, where severe skin wounds are resolved via scar tissue. This fibrotic response may be diminished by applying anti-fibrotic...
6.
Merx J, van Outersterp R, Engelke U, Hendriks V, Wevers R, Huigen M, et al.
Commun Biol
. 2022 Sep;
5(1):997.
PMID: 36131087
Hyperprolinemia type II (HPII) is an inborn error of metabolism due to genetic variants in ALDH4A1, leading to a deficiency in Δ-1-pyrroline-5-carboxylate (P5C) dehydrogenase. This leads to an accumulation of...
7.
Peters T, Merx J, Kooijman P, Noga M, de Boer S, van Gemert L, et al.
J Inherit Metab Dis
. 2022 Sep;
46(1):66-75.
PMID: 36088537
We used next-generation metabolic screening to identify new biomarkers for improved diagnosis and pathophysiological understanding of glucose transporter type 1 deficiency syndrome (GLUT1DS), comparing metabolic cerebrospinal fluid (CSF) profiles from...
8.
Sondag D, Merx J, Rossing E, Boltje T, Lowik D, Nelissen F, et al.
Chembiochem
. 2022 Jun;
23(15):e202200190.
PMID: 35649961
Since the outbreak of SARS-CoV-2 in December 2019 millions of infections have been reported globally. The viral chymotrypsin-like main protease (M ) exhibits a crucial role in viral replication and...
9.
Merx J, Houthuijs K, Elferink H, Witlox E, Mecinovic J, Oomens J, et al.
Chemistry
. 2021 Dec;
28(9):e202104078.
PMID: 34911145
N-Acyliminium ions are highly reactive intermediates that are important for creating CC-bonds adjacent to nitrogen atoms. Here we report the characterization of cyclic N-acyliminium ions in the gas phase, generated...
10.
Hintzen J, Merx J, Maas M, Langens S, White P, Boltje T, et al.
Org Biomol Chem
. 2021 Dec;
20(1):173-181.
PMID: 34877957
Histone lysine methyltransferases and acetyltransferases are two classes of epigenetic enzymes that play pivotal roles in human gene regulation. Although they both recognise and posttranslationally modify lysine residues in histone...