Jon M Kaguni
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Explore the profile of Jon M Kaguni including associated specialties, affiliations and a list of published articles.
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25
Citations
752
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Recent Articles
1.
Babu V, Homiski C, Scotland M, Chodavarapu S, Kaguni J, Sutton M
J Bacteriol
. 2021 Sep;
203(23):e0030421.
PMID: 34543109
Expression of the Escherichia coli -encoded β clamp at ≥10-fold higher than chromosomally expressed levels impedes growth by interfering with DNA replication. A mutant clamp (β bearing a glutamic acid-to-lysine...
2.
Homiski C, Scotland M, Babu V, Chodavarapu S, Maul R, Kaguni J, et al.
J Bacteriol
. 2021 Sep;
203(23):e0030321.
PMID: 34543108
Expression of the Escherichia coli -encoded β clamp at ≥10-fold higher than chromosomally expressed levels impedes growth by interfering with DNA replication. We hypothesized that the excess β clamp sequesters...
3.
Kaguni J
Antibiotics (Basel)
. 2018 Mar;
7(1).
PMID: 29538288
DNA replication is an essential process. Although the fundamental strategies to duplicate chromosomes are similar in all free-living organisms, the enzymes of the three domains of life that perform similar...
4.
Felczak M, Chodavarapu S, Kaguni J
J Biol Chem
. 2017 Oct;
292(51):20871-20882.
PMID: 29070678
Former studies relying on hydrogen/deuterium exchange analysis suggest that DnaC bound to DnaB alters the conformation of the N-terminal domain (NTD) of DnaB to impair the ability of this DNA...
5.
Kim J, Nanfara M, Chodavarapu S, Jin K, Babu V, Ghazy M, et al.
Nucleic Acids Res
. 2017 Feb;
45(7):3888-3905.
PMID: 28168278
Regulatory inactivation of DnaA (RIDA) is one of the major regulatory mechanisms of prokaryotic replication licensing. In RIDA, the Hda-sliding clamp complex loaded onto DNA directly interacts with adenosine triphosphate...
6.
Felczak M, Sage J, Hupert-Kocurek K, Aykul S, Kaguni J
J Biol Chem
. 2016 Jan;
291(9):4803-12.
PMID: 26728455
The DnaB-DnaC complex binds to the unwound DNA within the Escherichia coli replication origin in the helicase loading process, but the biochemical events that lead to its stable binding are...
7.
Chodavarapu S, Jones A, Feig M, Kaguni J
Nucleic Acids Res
. 2015 Oct;
44(1):210-20.
PMID: 26420830
Helicase loading at a DNA replication origin often requires the dynamic interactions between the DNA helicase and an accessory protein. In E. coli, the DNA helicase is DnaB and DnaC...
8.
Chodavarapu S, Felczak M, Simmons L, Murillo A, Kaguni J
Nucleic Acids Res
. 2013 Aug;
41(22):10254-67.
PMID: 23990329
DnaA is the initiator of DNA replication in bacteria. A mutant DnaA named DnaAcos is unusual because it is refractory to negative regulation. We developed a genetic method to isolate...
9.
Bell S, Kaguni J
Cold Spring Harb Perspect Biol
. 2013 Apr;
5(6).
PMID: 23613349
Loading of the replicative DNA helicase at origins of replication is of central importance in DNA replication. As the first of the replication fork proteins assemble at chromosomal origins of...
10.
Felczak M, Kaguni J
J Bacteriol
. 2012 Feb;
194(9):2152-64.
PMID: 22343303
Elevated levels of DnaA cause excessive initiation, which leads to an increased level of double-strand breaks that are proposed to arise when newly formed replication forks collide from behind with...