Jolien De Neve
Overview
Explore the profile of Jolien De Neve including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
22
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Recent Articles
1.
Breault E, Desgagne M, Neve J, Cote J, Barlow T, Ballet S, et al.
Pharmacol Res
. 2024 Sep;
209:107408.
PMID: 39307212
Chronic pain, which affects more than one-third of the world's population, represents one of the greatest medical challenges of the 21st century, yet its effective management remains sub-optimal. The 'gold...
2.
Neve J, Breault E, Previti S, Vangeloven E, Loranger B, Chartier M, et al.
ACS Pharmacol Transl Sci
. 2024 Sep;
7(9):2784-2798.
PMID: 39296263
Linking an opioid to a nonopioid pharmacophore represents a promising approach for reducing opioid-induced side effects during pain management. Herein, we describe the optimization of the previously reported opioid-neurotensin hybrids...
3.
Neve J, Elhabazi K, Gonzalez S, Herby C, Schneider S, Utard V, et al.
J Med Chem
. 2024 Apr;
67(9):7603-7619.
PMID: 38687204
The design of bifunctional compounds is a promising approach toward the development of strong analgesics with reduced side effects. We here report the optimization of the previously published lead peptide...
4.
Gadais C, Piekielna-Ciesielska J, Neve J, Martin C, Janecka A, Ballet S
Molecules
. 2021 Sep;
26(17).
PMID: 34500841
Opioid agonists are well-established analgesics, widely prescribed for acute but also chronic pain. However, their efficiency comes with the price of drastically impacting side effects that are inherently linked to...
5.
Neve J, Barlow T, Tourwe D, Bihel F, Simonin F, Ballet S
RSC Med Chem
. 2021 Jul;
12(6):828-870.
PMID: 34223156
One of the main challenges in contemporary medicinal chemistry is the development of safer analgesics, used in the treatment of pain. Currently, moderate to severe pain is still treated with...
6.
Dumitrascuta M, Bermudez M, Trovato O, Neve J, Ballet S, Wolber G, et al.
Molecules
. 2021 Jun;
26(11).
PMID: 34071603
Opioids are the most effective analgesics, with most clinically available opioids being agonists to the µ-opioid receptor (MOR). The MOR is also responsible for their unwanted effects, including reward and...