Joke Mertens
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Explore the profile of Joke Mertens including associated specialties, affiliations and a list of published articles.
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5
Citations
34
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Recent Articles
1.
Van Der Kelen A, Li Piani L, Mertens J, Regin M, Couvreu de Deckersberg E, Van de Velde H, et al.
Hum Reprod Open
. 2025 Jan;
2025(1):hoae074.
PMID: 39830711
Study Question: Is there an association between different mitochondrial DNA (mtDNA) genotypes and female infertility or ovarian response, and is the appearance of variants in the oocytes favored by medically...
2.
Mertens J, Belva F, van Montfoort A, Regin M, Zambelli F, Seneca S, et al.
Nat Commun
. 2024 Feb;
15(1):1232.
PMID: 38336715
Children conceived through assisted reproductive technologies (ART) have an elevated risk of lower birthweight, yet the underlying cause remains unclear. Our study explores mitochondrial DNA (mtDNA) variants as contributors to...
3.
Mertens J, Regin M, De Munck N, Couvreu de Deckersberg E, Belva F, Sermon K, et al.
Hum Mol Genet
. 2022 Mar;
31(21):3629-3642.
PMID: 35285472
Humans present remarkable diversity in their mitochondrial DNA (mtDNA) in terms of variants across individuals as well as across tissues and even cells within one person. We have investigated the...
4.
Mertens J, Zambelli F, Daneels D, Caljon B, Sermon K, Spits C
Bio Protoc
. 2021 Mar;
9(13):e3283.
PMID: 33654798
Detecting heteroplasmies in the mitochondrial DNA (mtDNA) has been a challenge for many years. In the past, Sanger sequencing was the main option to perform this analysis, however, this method...
5.
Zambelli F, Mertens J, Dziedzicka D, Sterckx J, Markouli C, Keller A, et al.
Stem Cell Reports
. 2018 Jun;
11(1):102-114.
PMID: 29910126
In this study, we deep-sequenced the mtDNA of human embryonic and induced pluripotent stem cells (hESCs and hiPSCs) and their source cells and found that the majority of variants pre-existed...
6.
Zambelli F, Vancampenhout K, Daneels D, Brown D, Mertens J, Van Dooren S, et al.
Eur J Hum Genet
. 2017 Aug;
25(11):1229-1236.
PMID: 28832570
Massive parallel sequencing (MPS) can accurately quantify mitochondrial DNA (mtDNA) single nucleotide variants (SNVs), but no MPS methods are currently validated to simultaneously and accurately establish the breakpoints and frequency...