John Soon Yew Lim
Overview
Explore the profile of John Soon Yew Lim including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
6
Citations
233
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0
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Recent Articles
1.
Tan C, Morenc M, Setiawan M, Lim Z, Soon A, Bierman J, et al.
Int J Mol Sci
. 2024 Aug;
25(15).
PMID: 39125721
-hydroxycinnamic acid (pHCA) is one of the most abundant naturally occurring hydroxycinnamic acids, a class of chemistries known for their antioxidant properties. In this study, we evaluated the impact of...
2.
Gong Q, Robinson K, Xu C, Huynh P, Chong K, Tan E, et al.
Nat Commun
. 2021 Jan;
12(1):188.
PMID: 33420028
Nod-like receptor (NLR) proteins activate pyroptotic cell death and IL-1 driven inflammation by assembling and activating the inflammasome complex. Closely related sensor proteins NLRP1 and CARD8 undergo unique auto-proteolysis-dependent activation...
3.
pS421 huntingtin modulates mitochondrial phenotypes and confers neuroprotection in an HD hiPSC model
Xu X, Ng B, Sim B, Radulescu C, Yusof N, Goh W, et al.
Cell Death Dis
. 2020 Sep;
11(9):809.
PMID: 32978366
Huntington disease (HD) is a hereditary neurodegenerative disorder caused by mutant huntingtin (mHTT). Phosphorylation at serine-421 (pS421) of mHTT has been shown to be neuroprotective in cellular and rodent models....
4.
Ramli M, Lim Y, Koe C, Demircioglu D, Tng W, Gonzales K, et al.
Gastroenterology
. 2020 Jun;
159(4):1471-1486.e12.
PMID: 32553762
Background & Aims: There are few in vitro models for studying the 3-dimensional interactions among different liver cell types during organogenesis or disease development. We aimed to generate hepatic organoids...
5.
Sudhaharan T, Hariharan S, Lim J, Liu J, Koon Y, Wright G, et al.
Sci Rep
. 2019 Feb;
9(1):2524.
PMID: 30792430
Superresolution microscopy offers the advantage of imaging biological structures within cells at the nano-scale. Here we apply two superresolution microscopy techniques, specifically 3D structured illumination microscopy (3D-SIM) and direct stochastic...
6.
Liu G, Yong M, Yurieva M, Srinivasan K, Liu J, Lim J, et al.
Cell
. 2015 Dec;
163(6):1388-99.
PMID: 26627736
Gene essentiality is typically determined by assessing the viability of the corresponding mutant cells, but this definition fails to account for the ability of cells to adaptively evolve to genetic...