John S Mattick
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Explore the profile of John S Mattick including associated specialties, affiliations and a list of published articles.
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207
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28634
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Recent Articles
1.
Bayraktar R, Tang Y, Dragomir M, Ivan C, Peng X, Fabris L, et al.
Sci Adv
. 2025 Feb;
11(8):eado2830.
PMID: 39970212
The mutational landscape of phylogenetically ultraconserved elements (UCEs), especially those in noncoding DNAs (ncUCEs), and their functional relevance in cancers remain poorly characterized. Here, we perform a systematic analysis of...
2.
Cummins M, Watson C, Edwards R, Mattick J
Mol Biol Evol
. 2024 Jul;
41(7).
PMID: 39058500
Ultraconserved elements were discovered two decades ago, arbitrarily defined as sequences that are identical over a length ≥ 200 bp in the human, mouse, and rat genomes. The definition was...
3.
Ersavas T, Smith M, Mattick J
Sci Rep
. 2024 May;
14(1):10000.
PMID: 38693215
Convolutional Neural Networks (CNNs) have been central to the Deep Learning revolution and played a key role in initiating the new age of Artificial Intelligence. However, in recent years newer...
4.
Werner A, Kanhere A, Wahlestedt C, Mattick J
Nat Rev Genet
. 2024 Apr;
25(10):730-744.
PMID: 38632496
Long non-coding RNAs (lncRNAs) are emerging as a major class of gene products that have central roles in cell and developmental biology. Natural antisense transcripts (NATs) are an important subset...
5.
Mattick J
Bioessays
. 2023 Jun;
45(9):e2300080.
PMID: 37318305
Thomas Kuhn described the progress of science as comprising occasional paradigm shifts separated by interludes of 'normal science'. The paradigm that has held sway since the inception of molecular biology...
6.
Enguita F, Leitao A, Mattick J
Int J Mol Sci
. 2023 May;
24(10).
PMID: 37240347
The central role of RNA molecules in cell biology has been an expanding subject of study since the proposal of the "RNA world" hypothesis 60 years ago [...].
7.
Mattick J, Amaral P, Carninci P, Carpenter S, Chang H, Chen L, et al.
Nat Rev Mol Cell Biol
. 2023 Jan;
24(6):430-447.
PMID: 36596869
Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II and Pol III...
8.
Begik O, Diensthuber G, Liu H, Delgado-Tejedor A, Kontur C, Niazi A, et al.
Nat Methods
. 2022 Dec;
20(1):75-85.
PMID: 36536091
RNA polyadenylation plays a central role in RNA maturation, fate, and stability. In response to developmental cues, polyA tail lengths can vary, affecting the translation efficiency and stability of mRNAs....
9.
Mattick J
Trends Genet
. 2022 Dec;
39(3):187-207.
PMID: 36528415
RNA has long been regarded primarily as the intermediate between genes and proteins. It was a surprise then to discover that eukaryotic genes are mosaics of mRNA sequences interrupted by...
10.
Begik O, Mattick J, Novoa E
RNA
. 2022 Sep;
28(11):1430-1439.
PMID: 36104106
Chemical RNA modifications, collectively referred to as the "epitranscriptome," are essential players in fine-tuning gene expression. Our ability to analyze RNA modifications has improved rapidly in recent years, largely due...