John R Zatarain
Overview
Explore the profile of John R Zatarain including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
251
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0
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Recent Articles
1.
Hellmich M, Chao C, Modis K, Ding Y, Zatarain J, Thanki K, et al.
Biomolecules
. 2021 Aug;
11(8).
PMID: 34439739
Upregulation of hydrogen sulfide (HS) biosynthesis, at least in part related to the upregulation of cystathionine β-synthetase (CBS) in cancer cells, serves as a tumor-promoting factor and has emerged as...
2.
Phillips C, Zatarain J, Nicholls M, Porter C, Widen S, Thanki K, et al.
Cancer Res
. 2017 Sep;
77(21):5741-5754.
PMID: 28923859
The trans-sulfuration enzyme cystathionine-β-synthase (CBS) and its product hydrogen sulfide (H2S) are aberrantly upregulated in colorectal cancers, where they contribute to tumor growth and progression by both autocrine and paracrine...
3.
Chao C, Widen S, Wood T, Zatarain J, Johnson P, Gajjar A, et al.
Anticancer Res
. 2017 Jul;
37(7):3405-3412.
PMID: 28668828
Background/aim: Patient-derived xenografting (PDX) of human colorectal cancer (CRC) is the preferred experimental model to study tumor response to therapeutic agents. Gradually, human stromal cells are replaced by mouse stromal...
4.
Szczesny B, Marcatti M, Zatarain J, Druzhyna N, Wiktorowicz J, Nagy P, et al.
Sci Rep
. 2016 Nov;
6:36125.
PMID: 27808278
Therapeutic manipulation of the gasotransmitter hydrogen sulfide (HS) has recently been proposed as a novel targeted anticancer approach. Here we show that human lung adenocarcinoma tissue expresses high levels of...
5.
Druzhyna N, Szczesny B, Olah G, Modis K, Asimakopoulou A, Pavlidou A, et al.
Pharmacol Res
. 2016 Aug;
113(Pt A):18-37.
PMID: 27521834
Cystathionine-β-synthase (CBS) has been recently identified as a drug target for several forms of cancer. Currently no potent and selective CBS inhibitors are available. Using a composite collection of 8871...
6.
Chao C, Zatarain J, Ding Y, Coletta C, Mrazek A, Druzhyna N, et al.
Mol Med
. 2016 Jun;
22:361-379.
PMID: 27257787
Colon cancer cells contain high levels of cystathionine-beta-synthase (CBS). Its product, hydrogen sulfide (HS) promotes the growth and proliferation of colorectal tumor cells. In order to improve the antitumor efficacy...
7.
de la Cruz J, Sally M, Zatarain J, Crutchfield M, Ramsey K, Nielsen J, et al.
J Trauma Acute Care Surg
. 2015 Jul;
79(4 Suppl 2):S164-70.
PMID: 26131787
Background: Historically, strategies to reduce acute rejection and improve graft survival in kidney transplant recipients included blood transfusions (BTs) before transplantation. While advents in recipient immunosuppression strategies have replaced this...