John R Osborne
Overview
Explore the profile of John R Osborne including associated specialties, affiliations and a list of published articles.
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Articles
4
Citations
3583
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Recent Articles
1.
Ley T, Ding L, Walter M, McLellan M, Lamprecht T, Larson D, et al.
N Engl J Med
. 2010 Nov;
363(25):2424-33.
PMID: 21067377
Background: The genetic alterations responsible for an adverse outcome in most patients with acute myeloid leukemia (AML) are unknown. Methods: Using massively parallel DNA sequencing, we identified a somatic mutation...
2.
Ley T, Mardis E, Ding L, Fulton B, McLellan M, Chen K, et al.
Nature
. 2008 Nov;
456(7218):66-72.
PMID: 18987736
Acute myeloid leukaemia is a highly malignant haematopoietic tumour that affects about 13,000 adults in the United States each year. The treatment of this disease has changed little in the...
3.
Ding L, Getz G, Wheeler D, Mardis E, McLellan M, Cibulskis K, et al.
Nature
. 2008 Oct;
455(7216):1069-75.
PMID: 18948947
Determining the genetic basis of cancer requires comprehensive analyses of large collections of histopathologically well-classified primary tumours. Here we report the results of a collaborative study to discover somatic mutations...
4.
Weir B, Woo M, Getz G, Perner S, Ding L, Beroukhim R, et al.
Nature
. 2007 Nov;
450(7171):893-8.
PMID: 17982442
Somatic alterations in cellular DNA underlie almost all human cancers. The prospect of targeted therapies and the development of high-resolution, genome-wide approaches are now spurring systematic efforts to characterize cancer...