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John Pappachan

Explore the profile of John Pappachan including associated specialties, affiliations and a list of published articles. Areas
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Articles 34
Citations 644
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Recent Articles
1.
Wosten-van Asperen R, la Roi-Teeuw H, Tissing W, Jordan I, Dohna-Schwake C, Bottari G, et al.
Pediatr Crit Care Med . 2025 Feb; 26(2):e177-e185. PMID: 39982155
Objectives: The Pediatric Sepsis Definition Task Force developed and validated a new organ dysfunction score, the Phoenix Sepsis Score (PSS), as a predictor of mortality in children with suspected or...
2.
Kapur A, Rojas-Anaya H, Roberts G, Roland D, Gupta A, Lazner M, et al.
ERJ Open Res . 2024 Oct; 10(5). PMID: 39377094
Background: Treating children with acute severe asthma (ASA) who fail to respond to first-line inhaled bronchodilators is problematic: use of intravenous agents is inconsistent and side-effects are common. High-flow humidified...
3.
Watson A, Zanetti F, Ross O, Pappachan J, Griksaitis M
Paediatr Anaesth . 2024 Sep; 35(1):77-78. PMID: 39306758
No abstract available.
4.
Jones G, Wiegand M, Ray S, Gould D, Agbeko R, Giallongo E, et al.
Pediatr Crit Care Med . 2024 Jul; 25(10):912-917. PMID: 39028216
Objectives: A conservative oxygenation strategy, targeting peripheral oxygen saturations (Sp o2 ) between 88% and 92% in mechanically ventilated children in PICU, was associated with a shorter duration of organ...
5.
Rojas-Anaya H, Kapur A, Roberts G, Roland D, Gupta A, Lazner M, et al.
JMIR Res Protoc . 2024 Mar; 13:e54081. PMID: 38546733
Background: Acute severe asthma (ASA) is a leading cause of hospital attendance in children. Standard first-line therapy consists of high-dose inhaled bronchodilators plus oral corticosteroids. Treatment for children who fail...
6.
Brown A, Ferrando-Vivas P, Popa M, de la Fuente G, Pappachan J, Cuthbertson B, et al.
Health Technol Assess . 2024 Feb; 28(8):1-84. PMID: 38421007
Background: Healthcare-associated infections are a major cause of morbidity and mortality in critically ill children. In adults, data suggest the use of selective decontamination of the digestive tract may reduce...
7.
Kean I, Clark J, Zhang Z, Daubney E, White D, Ferrando-Vivas P, et al.
Gut . 2024 Jan; 73(6):910-921. PMID: 38253478
Objective: Selective decontamination of the digestive tract (SDD) is a well-studied but hotly contested medical intervention of enhanced infection control. Here, we aim to characterise the changes to the microbiome...
8.
Pathan N, Woolfall K, Popa M, de la Fuente G, Ferrando-Vivas P, Brown A, et al.
Sci Rep . 2023 Dec; 13(1):21668. PMID: 38066012
Healthcare-associated infections (HCAIs) are a major cause of morbidity and mortality in critically ill children. Data from adult studies suggest Selective Decontamination of the Digestive tract (SDD) may reduce the...
9.
Wosten-van Asperen R, la Roi-Teeuw H, van Amstel R, Bos L, Tissing W, Jordan I, et al.
EClinicalMedicine . 2023 Oct; 65:102252. PMID: 37842550
Background: Identifying phenotypes in sepsis patients may enable precision medicine approaches. However, the generalisability of these phenotypes to specific patient populations is unclear. Given that paediatric cancer patients with sepsis...
10.
Baquedano M, de Jesus S, Rapetto F, Murphy G, Angelini G, Benedetto U, et al.
BMJ Open . 2023 Aug; 13(8):e071629. PMID: 37553192
Introduction: Congenital heart disease (CHD) represents the most common birth defect, affecting from 0.4% to 1.2% of children born in developed countries. The survival of these patients has increased significantly,...