John P Huggins
Overview
Explore the profile of John P Huggins including associated specialties, affiliations and a list of published articles.
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17
Citations
589
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Recent Articles
1.
Wanigasekera V, Wartolowska K, Huggins J, Duff E, Vennart W, Whitlock M, et al.
Br J Anaesth
. 2019 Apr;
123(2):e166-e171.
PMID: 30979518
No abstract available.
2.
Sanders D, Krause K, OMuircheartaigh J, Thacker M, Huggins J, Vennart W, et al.
Arthritis Rheumatol
. 2014 Dec;
67(3):741-51.
PMID: 25533872
Objective: In an attempt to shed light on management of chronic pain conditions, there has long been a desire to complement behavioral measures of pain perception with measures of underlying...
3.
OMuircheartaigh J, Marquand A, Hodkinson D, Krause K, Khawaja N, Renton T, et al.
Hum Brain Mapp
. 2014 Oct;
36(2):633-42.
PMID: 25307488
Recent reports of multivariate machine learning (ML) techniques have highlighted their potential use to detect prognostic and diagnostic markers of pain. However, applications to date have focussed on acute experimental...
4.
Bigal M, Escandon R, Bronson M, Walter S, Sudworth M, Huggins J, et al.
Cephalalgia
. 2013 Dec;
34(7):483-92.
PMID: 24366980
Background: LBR-101 is a fully humanized monoclonal antibody that binds to calcitonin gene-related peptide. Objective: The objective of this article is to characterize the safety and tolerability of LBR-101 when...
5.
Harris R, Napadow V, Huggins J, Pauer L, Kim J, Hampson J, et al.
Anesthesiology
. 2013 Dec;
119(6):1453-64.
PMID: 24343290
Background: Chronic pain remains a significant challenge for modern health care as its pathologic mechanisms are largely unknown and preclinical animal models suffer from limitations in assessing this complex subjective...
6.
Hodkinson D, Krause K, Khawaja N, Renton T, Huggins J, Vennart W, et al.
Neuroimage Clin
. 2013 Oct;
3:301-310.
PMID: 24143296
Arterial spin labelling (ASL) is increasingly being applied to study the cerebral response to pain in both experimental human models and patients with persistent pain. Despite its advantages, scanning time...
7.
Howard M, Sanders D, Krause K, OMuircheartaigh J, Fotopoulou A, Zelaya F, et al.
Arthritis Rheum
. 2012 Aug;
64(12):3936-46.
PMID: 22933378
Objective: Increasing evidence suggests a central nervous system (CNS) component underpinning persistent pain disease states. This study was undertaken to determine regional cerebral blood flow (rCBF) changes representing ongoing pain...
8.
Huggins J, Smart T, Langman S, Taylor L, Young T
Pain
. 2012 Jun;
153(9):1837-1846.
PMID: 22727500
The effect of PF-04457845, a potent and selective fatty acid amide hydrolase-1 (FAAH1) inhibitor, on pain due to osteoarthritis of the knee was investigated in a randomised placebo and active-controlled...
9.
Li G, Winter H, Arends R, Jay G, Le V, Young T, et al.
Br J Clin Pharmacol
. 2011 Nov;
73(5):706-16.
PMID: 22044402
Unlabelled: AIMS To evaluate the pharmacology and tolerability of PF-04457845, an orally available fatty acid amide hydrolase-1 (FAAH1) inhibitor, in healthy subjects. Methods: Double-blind, randomized, placebo-controlled single and multiple rising...
10.
Howard M, Krause K, Khawaja N, Massat N, Zelaya F, Schumann G, et al.
PLoS One
. 2011 Mar;
6(2):e17096.
PMID: 21373203
Development of treatments for acute and chronic pain conditions remains a challenge, with an unmet need for improved sensitivity and reproducibility in measuring pain in patients. Here we used pulsed-continuous...