John O Marentette
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Explore the profile of John O Marentette including associated specialties, affiliations and a list of published articles.
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19
Citations
213
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Recent Articles
1.
McGinnis C, Harris P, Graham B, Marentette J, Michel C, Saba L, et al.
Redox Biol
. 2024 Dec;
79():103462.
PMID: 39729908
Alcohol consumption induces hepatocyte damage through complex processes involving oxidative stress and disrupted metabolism. These factors alter proteomic and epigenetic marks, including alcohol-induced protein acetylation, which is a key post-translational...
2.
Harris P, McGinnis C, Michel C, Marentette J, Reisdorph R, Roede J, et al.
Redox Biol
. 2023 Jun;
64:102792.
PMID: 37390786
In the U.S., alcohol-associated liver disease (ALD) impacts millions of people and is a major healthcare burden. While the pathology of ALD is unmistakable, the molecular mechanisms underlying ethanol hepatotoxicity...
3.
Prutton K, Marentette J, Maclean K, Roede J
Free Radic Biol Med
. 2023 Jan;
196:11-21.
PMID: 36638900
Cellular redox state directs differentiation of induced pluripotent stem cells (iPSC) by energy metabolism control and ROS generation. As oxidative stress and mitochondrial dysfunction have been extensively reported in Down...
4.
Prutton K, Marentette J, Leifheit B, Esquer H, LaBarbera D, Anderson C, et al.
Free Radic Biol Med
. 2022 May;
186:32-42.
PMID: 35537597
The ubiquity of cognitive deficits and early onset Alzheimer's disease in Down syndrome (DS) has focused much DS iPSC-based research on neuron degeneration and regeneration. Despite reports of elevated oxidative...
5.
Anderson C, Marentette J, Prutton K, Rauniyar A, Reisz J, DAlessandro A, et al.
Free Radic Biol Med
. 2021 Jun;
172:201-212.
PMID: 34129926
Down syndrome (DS) is the most common genetic cause of intellectual disability. Mechanistically, oxidative stress and mitochondrial dysfunction are reported to be etiological factors for many of the DS-related comorbidities...
6.
Marentette J, Anderson C, Prutton K, Jennings E, Rauniyar A, Galligan J, et al.
Prostaglandins Other Lipid Mediat
. 2021 Jan;
153:106524.
PMID: 33418267
The triplication of human chromosome 21 results in Down syndrome (DS), the most common genetic form of intellectual disability. This aneuploid condition also results in an enhanced risk of a...
7.
Anderson C, Marentette J, Rauniyar A, Prutton K, Khatri M, Matheson C, et al.
Free Radic Biol Med
. 2020 Dec;
162:65-76.
PMID: 33279619
The dithiocarbamate fungicide maneb (MB) has attracted interest due to increasing concern of the negative health effects of pesticides, as well as its association with Parkinson's disease (PD). Our laboratory...
8.
Assiri M, Ali H, Marentette J, Yun Y, Liu J, Hirschey M, et al.
Hum Genomics
. 2019 Dec;
13(1):65.
PMID: 31823815
Background: Chronic alcohol consumption is a significant cause of liver disease worldwide. Several biochemical mechanisms have been linked to the initiation and progression of alcoholic liver disease (ALD) such as...
9.
Gaffney D, Jennings E, Anderson C, Marentette J, Shi T, Schou Oxvig A, et al.
Cell Chem Biol
. 2019 Nov;
27(2):206-213.e6.
PMID: 31767537
Post-translational modifications (PTMs) regulate enzyme structure and function to expand the functional proteome. Many of these PTMs are derived from cellular metabolites and serve as feedback and feedforward mechanisms of...
10.
Aivazidis S, Jain A, Rauniyar A, Anderson C, Marentette J, Orlicky D, et al.
PLoS One
. 2019 Nov;
14(11):e0223254.
PMID: 31714914
Down syndrome (DS) is a chromosomal disorder caused by trisomy of chromosome 21 (Ts21). Unbalanced karyotypes can lead to dysfunction of the proteostasis network (PN) and disrupted proteostasis is mechanistically...