John M Lopes
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Explore the profile of John M Lopes including associated specialties, affiliations and a list of published articles.
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16
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179
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Recent Articles
1.
Salas-Santiago B, Lopes J
G3 (Bethesda)
. 2014 Feb;
4(4):761-7.
PMID: 24558266
The overproduction and secretion of inositol (i.e., Opi(-)) phenotype is associated with defects in regulation of phospholipid biosynthesis in yeast. Here we report a screen of the essential yeast gene...
2.
Shetty A, Swaminathan A, Lopes J
J Mol Biol
. 2012 Nov;
425(3):457-65.
PMID: 23174187
Mechanisms for coregulation of transcription of tandem genes in yeast remain largely speculative. This study focused on inositol-mediated regulation of the tandem gene pair SNA3-INO1. While the pattern of regulation...
3.
He Y, Swaminathan A, Lopes J
Mol Microbiol
. 2011 Dec;
83(2):395-407.
PMID: 22182244
The Saccharomyces cerevisiae PHO5 gene product accounts for a majority of the acid phosphatase activity. Its expression is induced by the basic helix-loop-helix (bHLH) protein, Pho4p, in response to phosphate...
4.
Shetty A, Lopes J
Eukaryot Cell
. 2010 Oct;
9(12):1845-55.
PMID: 20935143
The Saccharomyces cerevisiae INO1 gene encodes the structural enzyme inositol-3-phosphate synthase for the synthesis de novo of inositol and inositol-containing phospholipids. The transcription of INO1 is completely derepressed in the...
5.
Chen L, Lopes J
Yeast
. 2010 Feb;
27(6):345-59.
PMID: 20162531
The basic helix-loop-helix (bHLH) proteins comprise a eukaryotic transcription factor family involved in multiple biological processes. They have the ability to form multiple dimer combinations and most of them also...
6.
Jani N, Lopes J
FEMS Yeast Res
. 2009 May;
9(4):552-64.
PMID: 19456874
Phosphatidylinositol is an important membrane lipid in Saccharomyces cerevisiae and other eukaryotes. Phosphatidylinositol and its metabolites (phosphoinositides, inositol polyphosphates, etc.) affect many cellular processes with implications in human diseases. Phosphatidylinositol...
7.
Jani N, Lopes J
Mol Microbiol
. 2008 Nov;
70(6):1529-39.
PMID: 19019152
In Saccharomyces cerevisiae, transcription of most of the phospholipid biosynthetic genes (e.g. INO1, CHO1, CHO2 and OPI3) is repressed by growth in the presence of inositol and choline and derepressed...
8.
Chen M, Lopes J
Eukaryot Cell
. 2007 Mar;
6(5):786-96.
PMID: 17351075
The basic helix-loop-helix (bHLH) eukaryotic transcription factors have the ability to form multiple dimer combinations. This property, together with limited DNA-binding specificity for the E box (CANNTG), makes them ideally...
9.
Chen M, Hancock L, Lopes J
Biochim Biophys Acta
. 2006 Jul;
1771(3):310-21.
PMID: 16854618
The last several years have been witness to significant developments in understanding transcriptional regulation of the yeast phospholipid structural genes. The response of most phospholipid structural genes to inositol is...
10.
Hancock L, Behta R, Lopes J
Genetics
. 2006 Apr;
173(2):621-34.
PMID: 16582425
Most of the phospholipid biosynthetic genes of Saccharomyces cerevisiae are coordinately regulated in response to inositol and choline. Inositol affects the intracellular levels of phosphatidic acid (PA). Opi1p is a...