John L Sensintaffar
Overview
Explore the profile of John L Sensintaffar including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
248
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0
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Recent Articles
1.
Zak K, Waterson A, Geist L, Braun N, Hauer K, Rumpel K, et al.
J Med Chem
. 2025 Jan;
68(3):2680-2693.
PMID: 39818983
The Son of Sevenless (SOS) protein family includes two highly homologous proteins, SOS1 and SOS2, that act as guanine nucleotide exchange factors (GEFs) for RAS proteins. They catalyze the GDP-to-GTP...
2.
Taylor A, Amporndanai K, Rietz T, Zhao B, Thiruvaipati A, Wei Q, et al.
ACS Med Chem Lett
. 2024 Aug;
15(8):1351-1357.
PMID: 39140055
Coronaviruses have been responsible for numerous viral outbreaks in the past two decades due to the high transmission rate of this family of viruses. The deadliest outbreak is the recent...
3.
Tarr J, Salovich J, Aichinger M, Jeon K, Veerasamy N, Sensintaffar J, et al.
J Med Chem
. 2024 Aug;
67(16):14370-14393.
PMID: 39102508
Myeloid cell leukemia 1 (Mcl-1) is a key regulator of the intrinsic apoptosis pathway. Overexpression of Mcl-1 is correlated with high tumor grade, poor survival, and both intrinsic and acquired...
4.
Teuscher K, Mills J, Tian J, Han C, Meyers K, Sai J, et al.
J Med Chem
. 2023 Dec;
66(24):16783-16806.
PMID: 38085679
The chromatin-associated protein WDR5 (WD repeat domain 5) is an essential cofactor for MYC and a conserved regulator of ribosome protein gene transcription. It is also a high-profile target for...
5.
Teuscher K, Chowdhury S, Meyers K, Tian J, Sai J, Van Meveren M, et al.
Proc Natl Acad Sci U S A
. 2022 Dec;
120(1):e2211297120.
PMID: 36574664
WD repeat domain 5 (WDR5) is a core scaffolding component of many multiprotein complexes that perform a variety of critical chromatin-centric processes in the nucleus. WDR5 is a component of...
6.
Tian J, Teuscher K, Aho E, Alvarado J, Mills J, Meyers K, et al.
J Med Chem
. 2019 Dec;
63(2):656-675.
PMID: 31858797
WD repeat domain 5 (WDR5) is a member of the WD40-repeat protein family that plays a critical role in multiple chromatin-centric processes. Overexpression of WDR5 correlates with a poor clinical...
7.
Lee T, Christov P, Shaw S, Tarr J, Zhao B, Veerasamy N, et al.
J Med Chem
. 2019 Apr;
62(8):3971-3988.
PMID: 30929420
Overexpression of myeloid cell leukemia-1 (Mcl-1) in cancers correlates with high tumor grade and poor survival. Additionally, Mcl-1 drives intrinsic and acquired resistance to many cancer therapeutics, including B cell...
8.
Shaw S, Bian Z, Zhao B, Tarr J, Veerasamy N, Jeon K, et al.
J Med Chem
. 2018 Jan;
61(6):2410-2421.
PMID: 29323899
Myeloid cell leukemia 1 (Mcl-1), an antiapoptotic member of the Bcl-2 family of proteins, has emerged as an attractive target for cancer therapy. Mcl-1 upregulation is often found in many...
9.
Lee T, Bian Z, Zhao B, Hogdal L, Sensintaffar J, Goodwin C, et al.
FEBS Lett
. 2016 Nov;
591(1):240-251.
PMID: 27878989
Pdb Id Codes: Comp. 2: 5IEZ; Comp. 5: 5IF4.
10.
Pelz N, Bian Z, Zhao B, Shaw S, Tarr J, Belmar J, et al.
J Med Chem
. 2016 Feb;
59(5):2054-66.
PMID: 26878343
Myeloid cell leukemia-1 (Mcl-1) is a member of the Bcl-2 family of proteins responsible for the regulation of programmed cell death. Amplification of Mcl-1 is a common genetic aberration in...