John J Seeley
Overview
Explore the profile of John J Seeley including associated specialties, affiliations and a list of published articles.
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6
Citations
383
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Recent Articles
1.
Seeley J, Baker R, Mohamed G, Bruns T, Hayden M, Deshmukh S, et al.
Nature
. 2018 Jun;
559(7712):114-119.
PMID: 29950719
Prolonged exposure to microbial products such as lipopolysaccharide can induce a form of innate immune memory that blunts subsequent responses to unrelated pathogens, known as lipopolysaccharide tolerance. Sepsis is a...
2.
Carneiro F, Lepelley A, Seeley J, Hayden M, Ghosh S
Cell Rep
. 2018 Mar;
22(10):2654-2666.
PMID: 29514094
ECSIT is a mitochondrial complex I (CI)-associated protein that has been shown to regulate the production of mitochondrial reactive oxygen species (mROS) following engagement of Toll-like receptors (TLRs). We have...
3.
Grinberg-Bleyer Y, Caron R, Seeley J, De Silva N, Schindler C, Hayden M, et al.
J Immunol
. 2018 Feb;
200(7):2362-2371.
PMID: 29459403
CD4Foxp3 regulatory T cells (Tregs) are essential regulators of immune responses. Perturbation of Treg homeostasis or function can lead to uncontrolled inflammation and autoimmunity. Therefore, understanding the molecular mechanisms involved...
4.
Seeley J, Ghosh S
J Leukoc Biol
. 2016 Oct;
101(1):107-119.
PMID: 27780875
LPS is a potent trigger of macrophage-mediated inflammation. However, prolonged exposure to LPS induces a state of tolerance that reprograms the inflammatory response, resulting in reduced inflammatory cytokine production in...
5.
Dainichi T, Hayden M, Park S, Oh H, Seeley J, Grinberg-Bleyer Y, et al.
Cell Rep
. 2016 May;
15(8):1615-23.
PMID: 27184845
Asymmetric cell division (ACD) in a perpendicular orientation promotes cell differentiation and organizes the stratified epithelium. However, the upstream cues regulating ACD have not been identified. Here, we report that...
6.
Seeley J, Ghosh S
Cold Spring Harb Symp Quant Biol
. 2014 Jul;
78:69-79.
PMID: 25028399
Lipopolysaccharide (LPS) is a potent inducer of inflammation. However, in a phenomenon known as LPS tolerance, prolonged exposure to LPS reprograms the host response to subsequent LPS reexposure. Proinflammatory cytokine...