John H McLean
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Explore the profile of John H McLean including associated specialties, affiliations and a list of published articles.
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15
Citations
244
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Recent Articles
1.
Nartey M, Pena-Castillo L, LeGrow M, Dore J, Bhattacharya S, Darby-King A, et al.
Learn Mem
. 2020 Apr;
27(5):209-221.
PMID: 32295841
In the olfactory bulb, a cAMP/PKA/CREB-dependent form of learning occurs in the first week of life that provides a unique mammalian model for defining the epigenetic role of this evolutionarily...
2.
Bhattacharya S, Mukherjee B, Dore J, Yuan Q, Harley C, McLean J
Learn Mem
. 2017 Sep;
24(10):543-551.
PMID: 28916629
Histone deacetylase (HDAC) plays a role in synaptic plasticity and long-term memory formation. We hypothesized that trichostatin-A (TSA), an HDAC inhibitor, would promote long-term odor preference memory and maintain enhanced...
3.
Modarresi S, Mukherjee B, McLean J, Harley C, Yuan Q
J Neurophysiol
. 2016 Apr;
116(2):404-10.
PMID: 27121578
After naturalistic odor preference training, Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) was rapidly phosphorylated in the olfactory bulb, specifically in the odor encoding regions of the glomerular layer and external plexiform...
4.
Grimes M, Powell M, Gutierrez S, Darby-King A, Harley C, McLean J
Learn Mem
. 2015 Jan;
22(2):74-82.
PMID: 25593293
Here we examine the role of the exchange protein directly activated by cAMP (Epac) in β-adrenergic-dependent associative odor preference learning in rat pups. Bulbar Epac agonist (8-pCPT-2-O-Me-cAMP, or 8-pCPT) infusions,...
5.
Grimes M, Harley C, Darby-King A, McLean J
Learn Mem
. 2012 Feb;
19(3):107-15.
PMID: 22354948
Neonatal odor-preference memory in rat pups is a well-defined associative mammalian memory model dependent on cAMP. Previous work from this laboratory demonstrates three phases of neonatal odor-preference memory: short-term (translation-independent),...
6.
Cui W, Darby-King A, Grimes M, Howland J, Wang Y, McLean J, et al.
Learn Mem
. 2011 Apr;
18(5):283-91.
PMID: 21498562
An increase in synaptic AMPA receptors is hypothesized to mediate learning and memory. AMPA receptor increases have been reported in aversive learning models, although it is not clear if they...
7.
Grimes M, Smith M, Li X, Darby-King A, Harley C, McLean J
Neurobiol Learn Mem
. 2011 Feb;
95(3):385-91.
PMID: 21296674
The ability of anisomycin, a translation inhibitor, and actinomycin, a transcription inhibitor to disrupt a cAMP/PKA-dependent odor preference memory in neonate rat was examined. Previous reports in invertebrates had described...
8.
McLean J, Smith A, Rogers S, Clarke K, Darby-King A, Harley C
Neurobiol Learn Mem
. 2009 Feb;
92(1):63-9.
PMID: 19233302
In various learning and memory models, preventing the breakdown of cyclic adenosine monophosphate (cAMP) by using a phosphodiesterase (PDE) inhibitor promotes memory. In the rat pup odor preference learning model...
9.
Cui W, Smith A, Darby-King A, Harley C, McLean J
Learn Mem
. 2007 Mar;
14(3):126-33.
PMID: 17337703
Increases in cyclic adenosine monophosphate (cAMP) are proposed to initiate learning in a wide variety of species. Here, we measure changes in cAMP in the olfactory bulb prior to, during,...
10.
Harley C, Darby-King A, McCann J, McLean J
Learn Mem
. 2006 Feb;
13(1):8-13.
PMID: 16452650
We proposed that mitral cell beta1-adrenoceptor activation mediates rat pup odor preference learning. Here we evaluate beta1-, beta2-, alpha1-, and alpha2-adrenoceptor agonists in such learning. The beta1-adrenoceptor agonist, dobutamine, and...