John G R Jefferys
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Explore the profile of John G R Jefferys including associated specialties, affiliations and a list of published articles.
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71
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2624
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Recent Articles
1.
Lisgaras C, de la Prida L, Bertram E, Cunningham M, Henshall D, Liu A, et al.
Epilepsia
. 2025 Feb;
PMID: 39913107
Electroencephalography (EEG) has been instrumental in epilepsy research for the past century, both for basic and translational studies. Its contributions have advanced our understanding of epilepsy, shedding light on the...
2.
Liska K, Pant A, Jefferys J
Neurobiol Dis
. 2024 Nov;
203:106735.
PMID: 39547479
Ictal central apnoea is a feature of focal temporal seizures. It is implicated as a risk factor for sudden unexpected death in epilepsy (SUDEP). Here we study seizure-related apnoeas in...
3.
Chvojka J, Prochazkova N, rehorova M, Kudlacek J, Kylarova S, Kralikova M, et al.
Neurobiol Dis
. 2023 Dec;
190:106383.
PMID: 38114051
High-frequency oscillations (HFOs) represent an electrographic biomarker of endogenous epileptogenicity and seizure-generating tissue that proved clinically useful in presurgical planning and delineating the resection area. In the neocortex, the clinical...
4.
Morris G, Avoli M, Bernard C, Connor K, de Curtis M, Dulla C, et al.
Epilepsia
. 2023 Aug;
64(10):2571-2585.
PMID: 37642296
In vitro preparations (defined here as cultured cells, brain slices, and isolated whole brains) offer a variety of approaches to modeling various aspects of seizures and epilepsy. Such models are...
5.
Biggs E, Budde R, Jefferys J, Irazoqui P
Epilepsy Behav
. 2022 Oct;
136:108918.
PMID: 36202052
Objective: To investigate carotid body (CB) mechanisms related to sudden death during seizure. Ictal activation of oxygen-conserving reflexes (OCRs) can trigger fatal cardiorespiratory collapse in seizing rats, which presents like...
6.
Lovick T, Jefferys J
Auton Neurosci
. 2021 Aug;
235:102864.
PMID: 34428716
The risk factors for SUDEP are undoubtedly heterogenous but the main factor is the frequency of generalized tonic-clonic seizures with apnoea and/or cardiac abnormalities likely precipitating the lethal event. By...
7.
Kudlacek J, Chvojka J, Kumpost V, Hermanovska B, Posusta A, Jefferys J, et al.
Neurobiol Dis
. 2021 Aug;
159:105484.
PMID: 34418569
No abstract available.
8.
Kudlacek J, Chvojka J, Kumpost V, Hermanovska B, Posusta A, Jefferys J, et al.
Neurobiol Dis
. 2021 Mar;
154:105347.
PMID: 33771663
The seemingly random and unpredictable nature of seizures is a major debilitating factor for people with epilepsy. An increasing body of evidence demonstrates that the epileptic brain exhibits long-term fluctuations...
9.
Biggs E, Budde R, Jefferys J, Irazoqui P
Epilepsia
. 2021 Feb;
62(3):752-764.
PMID: 33570173
Objective: To test the hypothesis that death with physiological parallels to human cases of sudden unexpected death in epilepsy (SUDEP) can be induced in seizing rats by ictal activation of...
10.
Budde R, Pederson D, Biggs E, Jefferys J, Irazoqui P
Epilepsy Behav
. 2020 Jun;
111:107188.
PMID: 32540771
Objective: Recent animal work and limited clinical data have suggested that laryngospasm may be involved in the cardiorespiratory collapse seen in sudden unexpected death in epilepsy (SUDEP). In previous work,...